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Neuropsychological Profile in Older Adults with End-Stage Kidney Disease during Kidney Transplantation Evaluation

dc.rights.licenseopenen_US
dc.contributor.authorPONGAN, Elodie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUCH, Isabelle
dc.contributor.authorVERNAUDON, Julien
dc.contributor.authorBACHELET, Romain
dc.contributor.authorNOVAIS, Teddy
dc.contributor.authorCOSTE, Marie-Helene
dc.contributor.authorEDJOLO, Arlette
dc.contributor.authorGARNIER-CRUSSARD, Antoine
dc.date.accessioned2025-04-11T08:03:19Z
dc.date.available2025-04-11T08:03:19Z
dc.date.issued2025-01-20
dc.identifier.issn1873-5843en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206128
dc.description.abstractEnBACKGROUND: End-stage chronic kidney disease (CKD) is a significant concern for older adults and is often associated with cognitive impairment (CI). The origin of this CI is multifactorial, involving vascular and metabolic factors. Additionally, renal treatments, including dialysis, may affect cognition. This study aimed to assess the neuropsychological profiles of these patients and understand the effects of dialysis treatment. METHODS: We conducted an observational retrospective study including older adults with end-stage CKD attending for kidney transplantation (KT). Comprehensive neuropsychological assessments were conducted. Composite cognitive scores were computed. Multivariate regression models were used to assess associations between cognition and dialysis status. RESULTS: We included 223 patients (151 treated with dialysis, 72 with conservative management), mean age of 73.5 ± 3.4. We observed a high prevalence of CI, around 30% for global cognition and affecting all neuropsychological domains. Patients treated with dialysis exhibited lower cognitive performance compared to those not undergoing dialysis, particularly in episodic (p = .031) and working memory (p = .024). CONCLUSION: This study confirms the high prevalence of CI in end-stage CKD, with dialysis being associated with worse episodic and working memory compared to non-dialyzed participants. Future investigations are needed to track the long-term cognitive trajectory of patients on the KT waiting list and post-transplantation. TRIAL REGISTRATION: Retrospectively registered, no 22-808 on July 7th, 2022, CNIL register number 22-5808.
dc.language.isoENen_US
dc.title.enNeuropsychological Profile in Older Adults with End-Stage Kidney Disease during Kidney Transplantation Evaluation
dc.title.alternativeArch Clin Neuropsycholen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/arclin/acaf001en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39829263en_US
bordeaux.journalArchives of Clinical Neuropsychologyen_US
bordeaux.pageacaf001en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Archives%20of%20Clinical%20Neuropsychology&rft.date=2025-01-20&rft.spage=acaf001&rft.epage=acaf001&rft.eissn=1873-5843&rft.issn=1873-5843&rft.au=PONGAN,%20Elodie&ROUCH,%20Isabelle&VERNAUDON,%20Julien&BACHELET,%20Romain&NOVAIS,%20Teddy&rft.genre=article


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