Water-accommodated fractions of heavy and light oils impact DNA integrity, embryonic development, and immune system of Japanese medaka at early life stages
| dc.rights.license | open | en_US |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | PANNETIER, Pauline | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | MORIN, Benedicte
IDREF: 178000892 | |
| hal.structure.identifier | Laboratoire de Ploufragan-Plouzané-Niort [ANSES] | |
| dc.contributor.author | CABON, Joëlle | |
| hal.structure.identifier | Laboratoire de Ploufragan-Plouzané-Niort [ANSES] | |
| hal.structure.identifier | Virologie, Immunologie et Ecotoxicologie des Poissons [VIMEP] | |
| dc.contributor.author | DANION, Morgane | |
| hal.structure.identifier | Laboratoire de Ploufragan-Plouzané-Niort [ANSES] | |
| hal.structure.identifier | Virologie, Immunologie et Ecotoxicologie des Poissons [VIMEP] | |
| dc.contributor.author | MORIN, Thierry | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | CLERANDEAU, Christelle | |
| hal.structure.identifier | Centre de documentation de recherche et d'expérimentations sur les pollutions accidentelles des eaux [Cedre] | |
| dc.contributor.author | LE FLOCH, Stéphane | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | CACHOT, Jérôme
ORCID: 0000-0002-1492-9684 IDREF: 19667672X | |
| dc.date.accessioned | 2025-03-28T09:55:44Z | |
| dc.date.available | 2025-03-28T09:55:44Z | |
| dc.date.issued | 2024-08-06 | |
| dc.identifier.issn | 0944-1344 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/205748 | |
| dc.description.abstractEn | Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants generally found in complex mixtures. PAHs are known to cause pleiotropic effects on living organisms, including developmental defects, mutagenicity, carcinogenicity and immunotoxicity, and endocrine disruptions. The main goal of this study is to evaluate the toxicity of water-accommodated fractions (WAFs) of oils in two life stages of the Japanese medaka, larvae and juveniles. The deleterious effects of an acute exposure of 48 h to two WAFs from Arabian light crude oil (LO) and refined oil from Erika (HO) were analyzed in both stages. Relevant endpoints, including ethoxy resorufin-O-deethylase (EROD) activity, DNA damage (Comet assay), photomotor response, and sensitivity to nervous necrosis virus (NNV) infection, were investigated. Larvae exposed to both oil WAFs displayed a significant induction of EROD activity, DNA damage, and developmental anomalies, but no behavioral changes. Deleterious effects were significantly increased following exposure to 1 and 10 μg/L of LO WAFs and 10 μg/L of HO WAFs. Larval infection to NNV induced fish mortality and sharply reduced reaction to light stimulation. Co-exposure to WAFs and NNV increased the mortality rate, suggesting an impact of WAFs on fish defense capacities. WAF toxicity on juveniles was only observed following the NNV challenge, with a higher sensitivity to HO WAFs than to LO WAFs. This study highlighted that environmentally realistic exposure to oil WAFs containing different compositions and concentrations of oil generated high adverse effects, especially in the larval stage. This kind of multi-marker approach is particularly relevant to characterize the toxicity fingerprint of environmental mixtures of hydrocarbons and PAHs. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. | |
| dc.language.iso | EN | en_US |
| dc.rights.uri | http://hal.archives-ouvertes.fr/licences/copyright/ | |
| dc.subject.en | Behavior | |
| dc.subject.en | Comet assay | |
| dc.subject.en | EROD activity | |
| dc.subject.en | Japanese medaka | |
| dc.subject.en | Malformations | |
| dc.subject.en | Oils | |
| dc.subject.en | PAHs | |
| dc.subject.en | Viral challenge | |
| dc.subject.en | Cell death | |
| dc.subject.en | DNA | |
| dc.subject.en | Fish | |
| dc.subject.en | Toxicity | |
| dc.subject.en | Viruses Comet assays | |
| dc.subject.en | Ethoxy resorufin-O-deethylase activity | |
| dc.subject.en | Malformation | |
| dc.subject.en | Oil | |
| dc.subject.en | Oil/water | |
| dc.subject.en | Resorufin | |
| dc.subject.en | Water accommodated fractions | |
| dc.subject.en | Polycyclic aromatic hydrocarbons | |
| dc.title.en | Water-accommodated fractions of heavy and light oils impact DNA integrity, embryonic development, and immune system of Japanese medaka at early life stages | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s11356-024-34604-z | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| bordeaux.journal | Environmental Science and Pollution Research | en_US |
| bordeaux.page | 50916-50928 | en_US |
| bordeaux.volume | 31 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.issue | 38 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | EA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | anses-04913812 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Science%20and%20Pollution%20Research&rft.date=2024-08-06&rft.volume=31&rft.issue=38&rft.spage=50916-50928&rft.epage=50916-50928&rft.eissn=0944-1344&rft.issn=0944-1344&rft.au=PANNETIER,%20Pauline&MORIN,%20Benedicte&CABON,%20Jo%C3%ABlle&DANION,%20Morgane&MORIN,%20Thierry&rft.genre=article |
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