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Water-accommodated fractions of heavy and light oils impact DNA integrity, embryonic development, and immune system of Japanese medaka at early life stages

dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPANNETIER, Pauline
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorMORIN, Benedicte
IDREF: 178000892
hal.structure.identifierLaboratoire de Ploufragan-Plouzané-Niort [ANSES]
dc.contributor.authorCABON, Joëlle
hal.structure.identifierLaboratoire de Ploufragan-Plouzané-Niort [ANSES]
hal.structure.identifierVirologie, Immunologie et Ecotoxicologie des Poissons [VIMEP]
dc.contributor.authorDANION, Morgane
hal.structure.identifierLaboratoire de Ploufragan-Plouzané-Niort [ANSES]
hal.structure.identifierVirologie, Immunologie et Ecotoxicologie des Poissons [VIMEP]
dc.contributor.authorMORIN, Thierry
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCLERANDEAU, Christelle
hal.structure.identifierCentre de documentation de recherche et d'expérimentations sur les pollutions accidentelles des eaux [Cedre]
dc.contributor.authorLE FLOCH, Stéphane
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCACHOT, Jérôme
ORCID: 0000-0002-1492-9684
IDREF: 19667672X
dc.date.accessioned2025-03-28T09:55:44Z
dc.date.available2025-03-28T09:55:44Z
dc.date.issued2024-08-06
dc.identifier.issn0944-1344en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205748
dc.description.abstractEnPolycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants generally found in complex mixtures. PAHs are known to cause pleiotropic effects on living organisms, including developmental defects, mutagenicity, carcinogenicity and immunotoxicity, and endocrine disruptions. The main goal of this study is to evaluate the toxicity of water-accommodated fractions (WAFs) of oils in two life stages of the Japanese medaka, larvae and juveniles. The deleterious effects of an acute exposure of 48 h to two WAFs from Arabian light crude oil (LO) and refined oil from Erika (HO) were analyzed in both stages. Relevant endpoints, including ethoxy resorufin-O-deethylase (EROD) activity, DNA damage (Comet assay), photomotor response, and sensitivity to nervous necrosis virus (NNV) infection, were investigated. Larvae exposed to both oil WAFs displayed a significant induction of EROD activity, DNA damage, and developmental anomalies, but no behavioral changes. Deleterious effects were significantly increased following exposure to 1 and 10 μg/L of LO WAFs and 10 μg/L of HO WAFs. Larval infection to NNV induced fish mortality and sharply reduced reaction to light stimulation. Co-exposure to WAFs and NNV increased the mortality rate, suggesting an impact of WAFs on fish defense capacities. WAF toxicity on juveniles was only observed following the NNV challenge, with a higher sensitivity to HO WAFs than to LO WAFs. This study highlighted that environmentally realistic exposure to oil WAFs containing different compositions and concentrations of oil generated high adverse effects, especially in the larval stage. This kind of multi-marker approach is particularly relevant to characterize the toxicity fingerprint of environmental mixtures of hydrocarbons and PAHs. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
dc.language.isoENen_US
dc.rights.urihttp://hal.archives-ouvertes.fr/licences/copyright/
dc.subject.enBehavior
dc.subject.enComet assay
dc.subject.enEROD activity
dc.subject.enJapanese medaka
dc.subject.enMalformations
dc.subject.enOils
dc.subject.enPAHs
dc.subject.enViral challenge
dc.subject.enCell death
dc.subject.enDNA
dc.subject.enFish
dc.subject.enToxicity
dc.subject.enViruses Comet assays
dc.subject.enEthoxy resorufin-O-deethylase activity
dc.subject.enMalformation
dc.subject.enOil
dc.subject.enOil/water
dc.subject.enResorufin
dc.subject.enWater accommodated fractions
dc.subject.enPolycyclic aromatic hydrocarbons
dc.title.enWater-accommodated fractions of heavy and light oils impact DNA integrity, embryonic development, and immune system of Japanese medaka at early life stages
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s11356-024-34604-zen_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalEnvironmental Science and Pollution Researchen_US
bordeaux.page50916-50928en_US
bordeaux.volume31en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue38en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifieranses-04913812
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Science%20and%20Pollution%20Research&rft.date=2024-08-06&rft.volume=31&rft.issue=38&rft.spage=50916-50928&rft.epage=50916-50928&rft.eissn=0944-1344&rft.issn=0944-1344&rft.au=PANNETIER,%20Pauline&MORIN,%20Benedicte&CABON,%20Jo%C3%ABlle&DANION,%20Morgane&MORIN,%20Thierry&rft.genre=article


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