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Comorbidities and HIV-related factors associated with mental health symptoms and unhealthy substance use among older adults living with HIV in low- and middle-income countries: a cross-sectional study

dc.rights.licenseopenen_US
dc.contributor.authorROSS, Jeremy L
dc.contributor.authorRUPASINGHE, Dhanushi
dc.contributor.authorCHANYACHUKUL, Thida
dc.contributor.authorCRABTREE RAMÍREZ, Brenda
dc.contributor.authorMURENZI, Gad
dc.contributor.authorKWOBAH, Edith
dc.contributor.authorMUREITHI, Fiona
dc.contributor.authorMINGA, Albert
dc.contributor.authorMARBANIANG, Ivan
dc.contributor.authorPERAZZO, Hugo
dc.contributor.authorPARCESEPE, Angela
dc.contributor.authorGOODRICH, Suzanne
dc.contributor.authorCHIMBETETE, Cleophas
dc.contributor.authorMENSAH, Ephrem
dc.contributor.authorMARURI, Fernanda
dc.contributor.authorTHI HOAI NGUYEN, Dung
dc.contributor.authorLÓPEZ-IÑIGUEZ, Alvaro
dc.contributor.authorLANCASTER, Kathryn
dc.contributor.authorBYAKWAGA, Helen
dc.contributor.authorTLALI, Mpho
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorPLAISY, Marie Kerbie
dc.contributor.authorNIMKAR, Smita
dc.contributor.authorMOREIRA, Rodrigo
dc.contributor.authorANASTOS, Kathryn
dc.contributor.authorSEMEERE, Aggrey
dc.contributor.authorWANDELER, Gilles
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorJAQUET, Antoine
dc.contributor.authorSOHN, Annette
dc.date.accessioned2025-03-26T12:14:19Z
dc.date.available2025-03-26T12:14:19Z
dc.date.issued2025-03-01
dc.identifier.issn1758-2652en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205692
dc.description.abstractEnPeople with HIV (PWH) are vulnerable to mental health and substance use disorders (MSDs), but the extent to which these are associated with other non-communicable diseases in ageing PWH populations remains poorly documented. We assessed comorbidities associated with symptoms of MSD among PWH ≥40 years in the Sentinel Research Network (SRN) of the International epidemiology Database to Evaluate AIDS (IeDEA). Baseline data collected between June 2020 and September 2022, from 10 HIV clinics in Asia, Latin America and Africa contributing to the SRN, were analysed. Symptoms of MSDs and comorbidities were assessed using standardized questionnaires, anthropometric and laboratory tests, including weight, height, blood pressure, glucose, lipids, chronic viral hepatitis and liver transient elastography. HIV viral load, CD4 count and additional routine clinical data were accessed from participant interview or medical records. HIV and non-HIV clinical associations of mental illness symptoms and unhealthy substance use were analysed using logistic regression. Mental illness symptoms were defined as moderate-to-severe depressive symptoms (PHQ-9 score >9), moderate-to-severe anxiety symptoms (GAD-7 >9) or probable post-traumatic stress disorder (PCL-5 >32). Unhealthy substance use was defined as ASSIST score >3, or AUDIT ≥7 for women (≥8 for men). Of 2614 participants assessed at baseline study visits, 57% were female, median age was 50 years, median CD4 was 548 cells/mm and 86% had HIV viral load 25 kg/m, 38% hypertension, 15% type 2 diabetes, 35% dyslipidaemia, 34% liver disease and 23% history of tuberculosis. BMI >25 and dyslipidaemia were found in 54% and 40% of those with mental illness symptoms compared to 49% and 34% of those without. Mental illness symptoms were not significantly associated with the clinical factors assessed. Unhealthy substance use was more likely among those with dyslipidaemia (OR 1.55, CI 1.16-2.09, p = 0.003), and less likely in those with BMI >25 (OR 0.48, CI 0.30-0.77, p = 0.009). Improved integration of MSD and comorbidity services in HIV clinical settings, and further research on the association between MSD and comorbidities, and care integration among older PWH in low-middle-income countries, are required.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHumans
dc.subject.enMale
dc.subject.enHIV Infections
dc.subject.enFemale
dc.subject.enCross-Sectional Studies
dc.subject.enMiddle Aged
dc.subject.enSubstance-Related Disorders
dc.subject.enComorbidity
dc.subject.enMental Disorders
dc.subject.enAged
dc.subject.enAdult
dc.subject.enDeveloping Countries
dc.subject.enMental Health
dc.title.enComorbidities and HIV-related factors associated with mental health symptoms and unhealthy substance use among older adults living with HIV in low- and middle-income countries: a cross-sectional study
dc.title.alternativeJ Int AIDS Socen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/jia2.26434en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40045453en_US
bordeaux.journalJournal of the International Aids Societyen_US
bordeaux.pagee26434en_US
bordeaux.volume28en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
bordeaux.identifier.funderIDNational Institute of Allergy and Infectious Diseasesen_US
bordeaux.identifier.funderIDEunice Kennedy Shriver National Institute of Child Health and Human Developmenten_US
bordeaux.identifier.funderIDNational Institutes of Healthen_US
bordeaux.identifier.funderIDFogarty International Centeren_US
bordeaux.import.sourcepubmed
hal.identifierhal-05006618
hal.version1
hal.date.transferred2025-03-26T12:14:24Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20the%20International%20Aids%20Society&rft.date=2025-03-01&rft.volume=28&rft.issue=3&rft.spage=e26434&rft.epage=e26434&rft.eissn=1758-2652&rft.issn=1758-2652&rft.au=ROSS,%20Jeremy%20L&RUPASINGHE,%20Dhanushi&CHANYACHUKUL,%20Thida&CRABTREE%20RAM%C3%8DREZ,%20Brenda&MURENZI,%20Gad&rft.genre=article


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