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Vectorisation et délivrance ciblée de médicaments ou gènes inductibles par des nanoparticules sensibles à l'hyperthermie sous contrôle de l'IRM - NanoBioImaging
dc.rights.license | open | |
hal.structure.identifier | Neuroinflammation: imagerie et thérapie de la sclérose en plaques | |
dc.contributor.author | PETRY, Klaus | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | VOISIN, Pierre | |
hal.structure.identifier | Imagerie Moléculaire et Nanobiotechnologies - Institut Européen de Chimie et Biologie [IECB] | |
dc.contributor.author | BRISSON, Alain | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
dc.contributor.author | DUGUET, Etienne | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | FRANCONI, Jean-Michel | |
hal.structure.identifier | Société Guerbetx | |
dc.contributor.author | IDÉE, Jean-Marc | |
hal.structure.identifier | Neuroinflammation: imagerie et thérapie de la sclérose en plaques | |
dc.contributor.author | BOIZIAU, Claudine
ORCID: 0000-0002-0475-2571 IDREF: 85228370 | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1959-0318 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20567 | |
dc.description.abstractEn | In experimental models of glioblastoma and Multiple sclerosis, we took advantage of molecular alterations of the neurovascular cells to address specific targeting via immune cells (monocytes, microglia) and ligands (antibodies and newly screened peptide ligands). The microglia cells were manipulated ex vivo for the heat sensitive expression of a therapeutic gene and incorporated a heat sensitive magnetic contrast agent. The ligands were labelled to carry both a magnetic contrast agent integrated in a heat sensitive cargo and a fluorescent maker. Upon i.v. administration, the manipulated microglia cells and the molecular ligand constructs targeted respectively, in vivo the tumour sites and the inflammatory alterations of lesions of the central nervous system (CNS) under the in vivo control of MRI that was confirmed by immunohistopathology. The approach is developed to associate target specific therapy and biomarkers in CNS diseases. | |
dc.language.iso | en | |
dc.publisher | Elsevier Masson | |
dc.subject.en | Microglia ligands | |
dc.subject.en | Thermosensitive and magnetic nanocargo hybrids MRI | |
dc.subject.en | Glioblastoma multiple sclerosis monocytes | |
dc.subject.en | Targeted delivery | |
dc.title | Vectorisation et délivrance ciblée de médicaments ou gènes inductibles par des nanoparticules sensibles à l'hyperthermie sous contrôle de l'IRM - NanoBioImaging | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1016/j.irbm.2011.01.034 | |
dc.subject.hal | Chimie/Matériaux | |
bordeaux.journal | Innovation and Research in BioMedical engineering | |
bordeaux.page | 185-190 | |
bordeaux.volume | 32 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 3 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | CNRS | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00618146 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00618146v1 | |
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