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In vitro and In vivo Evaluation of Docetaxel Loaded Biodegradable Polymersomes

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorUPADHYAY, Kamal Kumar
hal.structure.identifierDiv Radiat Biosci [DRDO, INMAS]
dc.contributor.authorBHATT, Anant
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorCASTRO, Emilio
hal.structure.identifierDiv Cyclotron & Radiopharmaceut Sci [DRDO, INMAS]
dc.contributor.authorMISHRA, Anil K.
hal.structure.identifierDiv Cyclotron & Radiopharmaceut Sci [DRDO, INMAS]
dc.contributor.authorCHUTTANI, Krishna
hal.structure.identifierDiv Radiat Biosci [DRDO, INMAS]
dc.contributor.authorDWARAKANATH, Bilikere
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
hal.structure.identifierPharm Dept, Fac Technol & Eng, Univ Baroda
dc.contributor.authorMISRA, Ambikanandan
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.created2010
dc.date.issued2010
dc.identifier.issn1616-5187
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20557
dc.description.abstractEnFormulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and showed controlled release behaviour over several days. PolyDOC showed high in vitro toxicity after 24h in MCF-7 and U87 cells compared to free DOC. Biodistribution data demonstrated that (99m)Tc labelled PolyDOC t(1/2) and MRT significantly increased compared to a DOC solution (DS). In addition, PolyDOC uptake in Ehrlich Ascites Tumor (EAT) tumor bearing mice was larger at each time point compared to DS, making such a polymer vesicle formulation an efficient drug nanocarrier for improved DOC cancer therapy.
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.subject.entumor uptake
dc.subject.enpolymersome
dc.subject.enhyaluronan
dc.subject.enbiodegradable
dc.subject.enbiodistribution
dc.subject.endocetaxel
dc.subject.endrug delivery systems
dc.title.enIn vitro and In vivo Evaluation of Docetaxel Loaded Biodegradable Polymersomes
dc.typeArticle de revue
dc.identifier.doi10.1002/mabi.200900415
dc.subject.halChimie/Polymères
bordeaux.journalMacromolecular Bioscience
bordeaux.page503-512
bordeaux.volume10
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue5
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00652855
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00652855v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Macromolecular%20Bioscience&rft.date=2010&rft.volume=10&rft.issue=5&rft.spage=503-512&rft.epage=503-512&rft.eissn=1616-5187&rft.issn=1616-5187&rft.au=UPADHYAY,%20Kamal%20Kumar&BHATT,%20Anant&CASTRO,%20Emilio&MISHRA,%20Anil%20K.&CHUTTANI,%20Krishna&rft.genre=article


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