In vitro and In vivo Evaluation of Docetaxel Loaded Biodegradable Polymersomes
dc.rights.license | open | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | UPADHYAY, Kamal Kumar | |
hal.structure.identifier | Div Radiat Biosci [DRDO, INMAS] | |
dc.contributor.author | BHATT, Anant | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | CASTRO, Emilio | |
hal.structure.identifier | Div Cyclotron & Radiopharmaceut Sci [DRDO, INMAS] | |
dc.contributor.author | MISHRA, Anil K. | |
hal.structure.identifier | Div Cyclotron & Radiopharmaceut Sci [DRDO, INMAS] | |
dc.contributor.author | CHUTTANI, Krishna | |
hal.structure.identifier | Div Radiat Biosci [DRDO, INMAS] | |
dc.contributor.author | DWARAKANATH, Bilikere | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | SCHATZ, Christophe | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LE MEINS, Jean-Francois | |
hal.structure.identifier | Pharm Dept, Fac Technol & Eng, Univ Baroda | |
dc.contributor.author | MISRA, Ambikanandan | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.created | 2010 | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1616-5187 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20557 | |
dc.description.abstractEn | Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and showed controlled release behaviour over several days. PolyDOC showed high in vitro toxicity after 24h in MCF-7 and U87 cells compared to free DOC. Biodistribution data demonstrated that (99m)Tc labelled PolyDOC t(1/2) and MRT significantly increased compared to a DOC solution (DS). In addition, PolyDOC uptake in Ehrlich Ascites Tumor (EAT) tumor bearing mice was larger at each time point compared to DS, making such a polymer vesicle formulation an efficient drug nanocarrier for improved DOC cancer therapy. | |
dc.language.iso | en | |
dc.publisher | Wiley-VCH Verlag | |
dc.subject.en | tumor uptake | |
dc.subject.en | polymersome | |
dc.subject.en | hyaluronan | |
dc.subject.en | biodegradable | |
dc.subject.en | biodistribution | |
dc.subject.en | docetaxel | |
dc.subject.en | drug delivery systems | |
dc.title.en | In vitro and In vivo Evaluation of Docetaxel Loaded Biodegradable Polymersomes | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1002/mabi.200900415 | |
dc.subject.hal | Chimie/Polymères | |
bordeaux.journal | Macromolecular Bioscience | |
bordeaux.page | 503-512 | |
bordeaux.volume | 10 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 5 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00652855 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00652855v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Macromolecular%20Bioscience&rft.date=2010&rft.volume=10&rft.issue=5&rft.spage=503-512&rft.epage=503-512&rft.eissn=1616-5187&rft.issn=1616-5187&rft.au=UPADHYAY,%20Kamal%20Kumar&BHATT,%20Anant&CASTRO,%20Emilio&MISHRA,%20Anil%20K.&CHUTTANI,%20Krishna&rft.genre=article |
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