Praliciguat Promotes Ischemic Leg Reperfusion in Leptin Receptor-Deficient Mice.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | FOUSSARD, Ninon | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | ROUAULT, Paul | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | CORNUAULT, Lauriane | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | REYNAUD, Annabel | |
| dc.contributor.author | BUYS, Emmanuel S | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | CHAPOULY, Candice | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | GADEAU, Alain-Pierre | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | COUFFINHAL, Thierry | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | RENAULT, Marie-Ange | |
| dc.date.accessioned | 2025-03-18T17:20:16Z | |
| dc.date.available | 2025-03-18T17:20:16Z | |
| dc.date.issued | 2023-01-06 | |
| dc.identifier.issn | 1524-4571 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/205538 | |
| dc.description.abstractEn | Lower-limb peripheral artery disease is one of the major complications of diabetes. Peripheral artery disease is associated with poor limb and cardiovascular prognoses, along with a dramatic decrease in life expectancy. Despite major medical advances in the treatment of diabetes, a substantial therapeutic gap remains in the peripheral artery disease population. Praliciguat is an orally available sGC (soluble guanylate cyclase) stimulator that has been reported both preclinically and in early stage clinical trials to have favorable effects in metabolic and hemodynamic outcomes, suggesting that it may have a potential beneficial effect in peripheral artery disease. We evaluated the effect of praliciguat on hind limb ischemia recovery in a mouse model of type 2 diabetes. Hind limb ischemia was induced in leptin receptor-deficient (Lepr) mice by ligation and excision of the left femoral artery. Praliciguat (10 mg/kg/day) was administered in the diet starting 3 days before surgery. Twenty-eight days after surgery, ischemic foot perfusion and function parameters were better in praliciguat-treated mice than in vehicle controls. Improved ischemic foot perfusion was not associated with either improved traditional cardiovascular risk factors (ie, weight, glycemia) or increased angiogenesis. However, treatment with praliciguat significantly increased arteriole diameter, decreased ICAM1 (intercellular adhesion molecule 1) expression, and prevented the accumulation of oxidative proangiogenic and proinflammatory muscle fibers. While investigating the mechanism underlying the beneficial effects of praliciguat therapy, we found that praliciguat significantly downregulated and mRNA expression in cultured myoblasts and that conditioned medium form praliciguat-treated myoblast decreased mRNA expression in endothelial cells. These results suggest that praliciguat therapy may decrease expression in endothelial cells by downregulating in myocytes. Our results demonstrated that praliciguat promotes blood flow recovery in the ischemic muscle of mice with type 2 diabetes, at least in part by increasing arteriole diameter and by downregulating ICAM1 expression. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Mice | |
| dc.subject.en | Animals | |
| dc.subject.en | Diabetes Mellitus | |
| dc.subject.en | Type 2 | |
| dc.subject.en | Receptors | |
| dc.subject.en | Leptin | |
| dc.subject.en | Endothelial Cells | |
| dc.subject.en | Ischemia | |
| dc.subject.en | Disease Models | |
| dc.subject.en | Animal | |
| dc.subject.en | Reperfusion | |
| dc.subject.en | Peripheral Arterial Disease | |
| dc.subject.en | Hindlimb | |
| dc.subject.en | Neovascularization | |
| dc.subject.en | Physiologic | |
| dc.subject.en | Muscle | |
| dc.subject.en | Skeletal | |
| dc.subject.en | Mice | |
| dc.subject.en | Inbred C57BL | |
| dc.title.en | Praliciguat Promotes Ischemic Leg Reperfusion in Leptin Receptor-Deficient Mice. | |
| dc.title.alternative | Circ Res | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1161/CIRCRESAHA.122.322033 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 36448444 | en_US |
| bordeaux.journal | Circulation Research | en_US |
| bordeaux.page | 34-48 | en_US |
| bordeaux.volume | 132 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04996210 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-03-18T17:20:18Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Circulation%20Research&rft.date=2023-01-06&rft.volume=132&rft.issue=1&rft.spage=34-48&rft.epage=34-48&rft.eissn=1524-4571&rft.issn=1524-4571&rft.au=FOUSSARD,%20Ninon&ROUAULT,%20Paul&CORNUAULT,%20Lauriane&REYNAUD,%20Annabel&BUYS,%20Emmanuel%20S&rft.genre=article |
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