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An Inversion Polymorphism Under Balancing Selection, Involving Giant Mobile Elements, in an Invasive Fungal Pathogen

hal.structure.identifierEcologie Systématique et Evolution [ESE]
dc.contributor.authorHARTMANN, Fanny
hal.structure.identifierEcologie Systématique et Evolution [ESE]
dc.contributor.authorRODRÍGUEZ DE LA VEGA, Ricardo
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorDEMENÉ, Arthur
hal.structure.identifierUniversité de Neuchâtel = University of Neuchatel [UNINE]
dc.contributor.authorBADET, Thomas
hal.structure.identifierEcologie Systématique et Evolution [ESE]
dc.contributor.authorVERNADET, Jean-Philippe
hal.structure.identifierEcologie Systématique et Evolution [ESE]
dc.contributor.authorROUGEMONT, Quentin
hal.structure.identifierEcologie Systématique et Evolution [ESE]
dc.contributor.authorLABAT, Amandine
hal.structure.identifierEcologie Systématique et Evolution [ESE]
dc.contributor.authorSNIRC, Alodie
hal.structure.identifierUniversität Bern = University of Bern = Université de Berne [UNIBE]
dc.contributor.authorSTAUBER, Lea
hal.structure.identifierUniversité de Neuchâtel = University of Neuchatel [UNINE]
dc.contributor.authorCROLL, Daniel
hal.structure.identifierSwiss Federal Institute for Forest, Snow and Landscape Research WSL
dc.contributor.authorPROSPERO, Simone
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorDUTECH, Cyril
hal.structure.identifierEcologie Systématique et Evolution [ESE]
dc.contributor.authorGIRAUD, Tatiana
dc.date.issued2025-02-03
dc.identifier.issn0737-4038
dc.description.abstractEnRecombination suppression can evolve in sex or mating-type chromosomes, or in autosomal supergenes, with different haplotypes being maintained by balancing selection. In the invasive chestnut blight fungus Cryphonectria parasitica, a genomic region was suggested to lack recombination and to be partially physically linked to the mating-type (MAT) locus based on segregation analyses. Using hundreds of available C. parasitica genomes and generating new high-quality genome assemblies, we show that a ca. 1.2 Mb genomic region proximal to the mating-type locus lacks recombination, with the segregation of two highly differentiated haplotypes in balanced proportions in invasive populations. High-quality genome assemblies further revealed an inversion in one of the haplotypes in the invaded range. The two haplotypes were estimated to have diverged 1.5 million years ago, and each harboured specific genes, some of which likely belonging to Starships. These are large transposable elements, mobilized by tyrosine recombinases, able to move accessory genes, and involved in adaptation in multiple fungi. The MAT-proximal region carried genes upregulated under virus infection or vegetative incompatibility reaction. In the native range, the MAT-proximal region also appeared to have a different evolutionary history than the rest of the genome. In all continents, the MAT-Proximal region was enriched in nonsynonymous substitutions, in gene presence/absence polymorphism, in tyrosine recombinases and in transposable elements. This study thus sheds light on a case of a large nonrecombining region partially linked to a mating compatibility locus, likely maintained by balancing selection on differentiated haplotypes, possibly involved in adaptation in a devastating tree pathogen.
dc.description.sponsorshipIDéES@UGA - ANR-20-IDES-0005
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enrecombination suppression
dc.subject.enfungi
dc.subject.enmating-type chromosome
dc.subject.eninversion
dc.subject.endeleterious allele sheltering
dc.subject.ensupergenes
dc.subject.enevolutionary strata
dc.subject.ensex chromosomes
dc.subject.enStarships
dc.title.enAn Inversion Polymorphism Under Balancing Selection, Involving Giant Mobile Elements, in an Invasive Fungal Pathogen
dc.typeArticle de revue
dc.identifier.doi10.1093/molbev/msaf026
dc.subject.halSciences de l'environnement
bordeaux.journalMolecular Biology and Evolution
bordeaux.volume42
bordeaux.issue2
bordeaux.peerReviewedoui
hal.identifierhal-04987859
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04987859v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20Biology%20and%20Evolution&rft.date=2025-02-03&rft.volume=42&rft.issue=2&rft.eissn=0737-4038&rft.issn=0737-4038&rft.au=HARTMANN,%20Fanny&RODR%C3%8DGUEZ%20DE%20LA%20VEGA,%20Ricardo&DEMEN%C3%89,%20Arthur&BADET,%20Thomas&VERNADET,%20Jean-Philippe&rft.genre=article


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