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Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences

dc.rights.licenseopenen_US
dc.contributor.authorBOULIANE, Mélanie
dc.contributor.authorBOIVIN, Michel
dc.contributor.authorKRETSCHMER, Tina
dc.contributor.authorLAFRENIERE, Bianca
dc.contributor.authorPAQUIN, Stéphane
dc.contributor.authorTREMBLAY, Richard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
ORCID: 0000-0001-7944-0647
dc.contributor.authorGOUIN, Jean-Philippe
dc.contributor.authorANDLAUER, Till F M
dc.contributor.authorPETITCLERC, Amélie
dc.contributor.authorOUELLET-MORIN, Isabelle
dc.date.accessioned2025-03-12T14:59:47Z
dc.date.available2025-03-12T14:59:47Z
dc.date.issued2025-02-05
dc.identifier.issn1435-165Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205481
dc.description.abstractEnIndividual differences in physical aggression (PA) are largely heritable. However, it remains unclear how genetic propensity for aggression manifests early in life and relates to school-age PA. Preschool externalizing behavior problems (EXT) and adverse experiences are known predictors of school-age PA and also partly heritable. We investigated whether early childhood EXT and adverse experiences mediated the association between polygenic scores and school-age PA. Genotype data collected from 721 participants in the Quebec Longitudinal Study of Child Development (45% males) were used to derive polygenic scores for aggression (PGS) and attention deficit/hyperactivity disorder (PGS). PA was reported annually or biennially on six occasions between ages 6 and 13 by distinct teachers. Mothers reported EXT (PA, hyperactivity, opposition) and adverse experiences (peer difficulties and harsh parenting) on three occasions between ages 3½ and 5. Both PGSs proved significant predictors of school-age PA. However, no early behaviors or adverse experiences mediated the association between PGS and school-age PA. Contrastingly, hyperactivity and opposition each partially mediated the association between PGS and school-age PA. Notably, when both mediators were included in the same model, only hyperactivity remained significant. This study contributes to identifying early manifestations of genetic risk for PA, which may serve as early targets for intervention.
dc.language.isoENen_US
dc.subject.enAdverse experiences
dc.subject.enAggression
dc.subject.enAttention deficit/hyperactivity disorder
dc.subject.enExternalizing behavior problems
dc.subject.enLongitudinal study
dc.subject.enPolygenic score
dc.title.enAssociation between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences
dc.title.alternativeEur Child Adolesc Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00787-025-02654-4en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39907790en_US
bordeaux.journalEuropean Child and Adolescent Psychiatryen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04988216
hal.version1
hal.date.transferred2025-03-12T14:59:49Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Child%20and%20Adolescent%20Psychiatry&rft.date=2025-02-05&rft.eissn=1435-165X&rft.issn=1435-165X&rft.au=BOULIANE,%20M%C3%A9lanie&BOIVIN,%20Michel&KRETSCHMER,%20Tina&LAFRENIERE,%20Bianca&PAQUIN,%20St%C3%A9phane&rft.genre=article


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