Body-weight Cycling and Risk of Diabetic Kidney Disease in People With Type 1 Diabetes in the DCCT/EDIC Population.
| dc.rights.license | open | en_US |
| dc.contributor.author | CAMOIN, Marion | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| dc.contributor.author | SAULNIER, Pierre-Jean | |
| dc.contributor.author | HADJADJ, Samy | |
| dc.contributor.author | GAUTIER, Jean-François | |
| dc.contributor.author | RIVELINE, Jean-Pierre | |
| dc.contributor.author | VENTECLEF, Nicolas | |
| dc.contributor.author | POTIER, Louis | |
| dc.contributor.author | VELHO, Gilberto | |
| dc.date.accessioned | 2025-03-04T13:55:08Z | |
| dc.date.available | 2025-03-04T13:55:08Z | |
| dc.date.issued | 2025-02-04 | |
| dc.identifier.issn | 1945-7197 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/205348 | |
| dc.description.abstractEn | Intraindividual body-weight variability or cycling is associated with increased risk of chronic kidney disease (CKD) in the general population. We conducted a retrospective analysis of data from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) studies to assess association between body-weight cycling and the risk of renal events in type 1 diabetes. Four indices of intraindividual body-weight variability were calculated for 1432 participants of DCCT/EDIC taking into account body-weight measurements during the DCCT follow-up (6 ± 2 years). Variability independent of the mean (VIM) was the main index. Six criteria of progression to CKD were studied during DCCT/EDIC follow-up (21 ± 4 years). Hazard ratio (HR) with 95% confidence interval (CI) were computed in Cox analyses for 1 SD of the indices expressed as Z-score. A high VIM was significantly associated with the incidence of a 40% decline in eGFR from baseline values (HR, 1.25; 95% CI, 1.09-1.41; P = .001), doubling of baseline serum creatinine (HR, 1.34; 95% CI, 1.13-1.57; P = .001), CKD stage 3 (HR, 1.36; 95% CI, 1.12-1.63; P = .002), and with a decline in eGFR > 3 mL/min/m2 per year (all analyses adjusted for CKD risk factors at baseline and follow-up, and use of nephroprotective drugs). VIM was also associated with the incidence of moderately and severely increased albuminuria, but associations did not remain significant following adjustment for follow-up covariates. Similar results were observed for the other indices of body-weight cycling. Body-weight cycling is significantly associated with an increased risk of kidney events in people with type 1 diabetes, regardless of body mass index and traditional risk factors. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Body-weight Cycling and Risk of Diabetic Kidney Disease in People With Type 1 Diabetes in the DCCT/EDIC Population. | |
| dc.title.alternative | J Clin Endocrinol Metab | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1210/clinem/dgae852 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 39902910 | en_US |
| bordeaux.journal | Journal of Clinical Endocrinology and Metabolism | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04976238 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-03-04T13:55:10Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Endocrinology%20and%20Metabolism&rft.date=2025-02-04&rft.eissn=1945-7197&rft.issn=1945-7197&rft.au=CAMOIN,%20Marion&MOHAMMEDI,%20Kamel&SAULNIER,%20Pierre-Jean&HADJADJ,%20Samy&GAUTIER,%20Jean-Fran%C3%A7ois&rft.genre=article |
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