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Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants

hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorPÉREZ-SANCHO, Jessica
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorSMOKVARSKA, Marija
hal.structure.identifierReproduction et développement des plantes [RDP]
dc.contributor.authorGWENNOGAN, Dubois
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorGLAVIER, Marie
hal.structure.identifierLaboratoire de biochimie théorique [Paris] [LBT (UPR_9080)]
dc.contributor.authorSRITHARAN, Sujith
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorMORAES, Tatiana
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorMOREAU, Hortense
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorDIETRICH, Victor
hal.structure.identifierThe Salk Institute for Biological Studies
dc.contributor.authorPLATRE, Matthieu
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
hal.structure.identifierSainsbury Laboratory Cambridge University [SLCU]
dc.contributor.authorPATERLINI, Andrea
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorLI, Ziqiang
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorFOUILLEN, Laetitia
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorGRISON, Magali
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorCANA-QUIJADA, Pepe
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorIMMEL, Françoise
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorWATTELET, Valerie
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorDUCROS, Mathieu
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorBROCARD, Lysiane
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorCHAMBAUD, Clément
hal.structure.identifierUniversiteit Gent = Ghent University = Université de Gand [UGENT]
hal.structure.identifierCenter for Plant Systems Biology [PSB Center]
dc.contributor.authorLUO, Yongming
hal.structure.identifierUniversité de Genève = University of Geneva [UNIGE]
dc.contributor.authorRAMAKRISHNA, Priya
hal.structure.identifierReproduction et développement des plantes [RDP]
dc.contributor.authorBAYLE, Vincent
hal.structure.identifierUniversité de Genève = University of Geneva [UNIGE]
dc.contributor.authorLEFEBVRE-LEGENDRE, Linnka
hal.structure.identifierPlateforme Protéome [Bordeaux]
dc.contributor.authorCLAVEROL, Stéphane
hal.structure.identifierUniversity of St Andrews [Scotland]
hal.structure.identifierThe James Hutton Institute
dc.contributor.authorZABRADY, Matej
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorMARTIN, Pascal G.P.
hal.structure.identifierThe Salk Institute for Biological Studies
dc.contributor.authorBUSCH, Wolfgang
hal.structure.identifierUniversité de Genève = University of Geneva [UNIGE]
dc.contributor.authorBARBERON, Marie
hal.structure.identifierUniversity of St Andrews [Scotland]
hal.structure.identifierThe James Hutton Institute
dc.contributor.authorTILSNER, Jens
hal.structure.identifierSainsbury Laboratory Cambridge University [SLCU]
hal.structure.identifierViikki Plant Science Centre [ViPS]
hal.structure.identifierHelsingin yliopisto = Helsingfors universitet = University of Helsinki
dc.contributor.authorHELARIUTTA, Yrjö
hal.structure.identifierUniversiteit Gent = Ghent University = Université de Gand [UGENT]
hal.structure.identifierCenter for Plant Systems Biology [PSB Center]
dc.contributor.authorRUSSINOVA, Eugenia
hal.structure.identifierLaboratoire de biochimie théorique [Paris] [LBT (UPR_9080)]
dc.contributor.authorTALY, Antoine
hal.structure.identifierReproduction et développement des plantes [RDP]
dc.contributor.authorJAILLAIS, Yvon
hal.structure.identifierLaboratoire de biogenèse membranaire [LBM]
dc.contributor.authorBAYER, Emmanuelle
dc.date.issued2025-02
dc.identifier.issn0092-8674
dc.description.abstractEnMembrane contact sites (MCSs) are fundamental for intracellular communication, but their role in intercellular communication remains unexplored. We show that in plants, plasmodesmata communication bridges function as atypical endoplasmic reticulum (ER)-plasma membrane (PM) tubular MCSs, operating at cell-cell interfaces. Similar to other MCSs, ER-PM apposition is controlled by a protein-lipid tethering complex, but uniquely, this serves intercellular communication. Combining high-resolution microscopy, molecular dynamics, and pharmacological and genetic approaches, we show that cell-cell trafficking is modulated through the combined action of multiple C2 domains transmembrane domain proteins (MCTPs) 3, 4, and 6 ER-PM tethers and phosphatidylinositol-4-phosphate (PI4P) lipid. Graded PI4P amounts regulate MCTP docking to the PM, their plasmodesmata localization, and cell-cell permeability. SAC7, an ER-localized PI4P-phosphatase, regulates MCTP4 accumulation at plasmodesmata and modulates cell-cell trafficking capacity in a cell-type-specific manner. Our findings expand MCS functions in information transmission from intracellular to intercellular cellular activities.
dc.description.sponsorshipDéveloppement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée
dc.description.sponsorshipCONTACTS MEMBRANAIRES ET LE CONTROLE DE LA COMMUNICATION INTERCELLULAIRE CHEZ LES PLANTES
dc.description.sponsorshipComment la communication de cellule à cellule régule-t'elle la croissance du fruit ? - ANR-20-CE20-0002
dc.description.sponsorshipDiviser et connecter: mise en place de la communication intercellulaire pendant la division cellulaire
dc.description.sponsorshipMécanismes du pattern lipidique du réseau trans-Golgien (trans-Golgi Network) et rôles dans le tri des protéines, la polarité cellulaire et le développement des plantes
dc.language.isoen
dc.publisherElsevier
dc.title.enPlasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants
dc.typeArticle de revue
dc.identifier.doi10.1016/j.cell.2024.11.034
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire
dc.description.sponsorshipEuropeThe function of membrane tethering in plant intercellular communication
dc.description.sponsorshipEuropeLipid gradients and the dynamics of the plant endomembrane system: from the nano- to the developmental scales
bordeaux.journalCell
bordeaux.page958-977.e23
bordeaux.volume188
bordeaux.issue4
bordeaux.peerReviewedoui
hal.identifierhal-04963028
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04963028v1
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