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In vitro inhibitory effect of tetrahydrocurcuminoids on Fusarium proliferatum growth and fumonisin B(1) biosynthesis

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 2 LCPO : Biopolymers & Bio-sourced Polymers
dc.contributor.authorCOMA, Veronique
hal.structure.identifierUnité des Sciences du bois et des biopolymères [Us2b]
dc.contributor.authorPORTES, Elise
hal.structure.identifierUnité des Sciences du bois et des biopolymères [Us2b]
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorGARDRAT, Christian
dc.contributor.authorRICHARD-FORGET, Florence
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorCASTELLAN, Alain
dc.date.accessioned2020
dc.date.available2020
dc.date.created2011
dc.date.issued2011
dc.identifier.issn0265-203X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20516
dc.description.abstractEnMany plant pathogens produce toxic metabolites when growing on food and feed. Some antioxidative components seem to prevent fungal growth and mycotoxin formation. Recently, we synthesized a new class of powerful antioxidative compounds, i.e. tetrahydrocurcuminoids, and its structure/antioxidant activity relationships have been established. The South West of France produces large amounts of corn, which can be infected by Fusarium species, particularly F. proliferatum. In this context, the efficiency of tetrahydrocurcuminoids, which can be obtained from natural curcuminoids, was investigated to control invitro the growth of F. proliferatum and the production of its associated mycotoxin, fumonisin B1. The relation between structure and antifungal activity was studied. Tetrahydrocurcumin (THC1), with two guaiacyl phenolic subunits, showed the highest inhibitory activity (measured as radial growth on agar medium) against the F. proliferatum development (67% inhibition at a concentration of 13.6 mu mol ml-1). The efficiencies of THC2 (36% at a concentration of 11.5 mu mol ml-1), which contains syringyl phenolic units, and THC3 (30% at a concentration of 13.6 mu mol ml-1), which does not have any substituent on the aromatic rings, were relatively close. These results indicate that the simultaneous presence of guaiacyl phenols and the enolic function of the -diketone moiety play an important role in the inhibition mechanisms. The importance of this combination was confirmed using n-propylguaiacol and acetylacetone as molecular models. Under the same conditions, ferulic acid and eugenol, other natural phenolic antioxidants, were less efficient in inhibiting fungal growth. THC1 also reduced fumonisin B1 production in liquid medium by approximately 35, 50 and 75% at concentrations of 0.8, 1.3, and 1.9 mu mol ml-1, respectively. These very low inhibitory concentrations show that tetrahydrocurcuminoids could be one of the most promising biobased molecules for the control of mycotoxinogen fungal strains.
dc.language.isoen
dc.publisherInforma UK (Taylor & Francis)
dc.subject.encereals
dc.subject.enfungi
dc.subject.enmycotoxins
dc.subject.enfumonisins
dc.subject.enmicrobiology
dc.subject.enantioxidants
dc.title.enIn vitro inhibitory effect of tetrahydrocurcuminoids on Fusarium proliferatum growth and fumonisin B(1) biosynthesis
dc.typeArticle de revue
dc.identifier.doi10.1080/19440049.2010.540721
dc.subject.halChimie/Polymères
bordeaux.journalFood additives and contaminants
bordeaux.page218-225
bordeaux.volume28
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue2
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00679482
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00679482v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Food%20additives%20and%20contaminants&rft.date=2011&rft.volume=28&rft.issue=2&rft.spage=218-225&rft.epage=218-225&rft.eissn=0265-203X&rft.issn=0265-203X&rft.au=COMA,%20Veronique&PORTES,%20Elise&GARDRAT,%20Christian&RICHARD-FORGET,%20Florence&CASTELLAN,%20Alain&rft.genre=article


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