Neuroretinal and RPE changes and susceptibility to Age-Related Macular Degeneration: insights from the longitudinal Alienor Study
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LARSEN, Petra P | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELYFER, Marie-Noelle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SCHWEITZER, Cedric | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535 IDREF: 028739272 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELCOURT, Cecile
ORCID: 0000-0002-2099-0481 IDREF: 035105291 | |
| dc.date.accessioned | 2025-02-19T12:59:32Z | |
| dc.date.available | 2025-02-19T12:59:32Z | |
| dc.date.issued | 2025-01-08 | |
| dc.identifier.issn | 0161-6420 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/205040 | |
| dc.description.abstractEn | PURPOSE: We assessed the associations of macular layer thicknesses, measured using spectral-domain OCT (SD-OCT), with incident age-related macular degeneration (AMD) and AMD polygenic risk scores (PRS). DESIGN: Population-based cohort study PARTICIPANTS: 653 participants of the Alienor study, with biennial eye imaging from 2009 to 2024. METHODS: Macular layer thicknesses of eight distinct layers and three compound layers were automatically segmented based on SD-OCT imaging of the macula. Total and pathway specific PRS were calculated from previous AMD genome-wide association studies summary statistics. Associations of macular layer thicknesses with incident intermediate and advanced AMD were analyzed using time-dependent Cox proportional hazards models. Associations of macular layer thicknesses with PRS were assessed using linear mixed models. MAIN OUTCOME MEASURES: Incident intermediate and advanced AMD based on fundus colour photographs and SD-OCT. RESULTS: Mean age at first OCT examination of the 653 participants was 82.2 ± 4.2 years and 61.3 % were women. In multivariate adjusted models, incident intermediate AMD was associated with thicker retinal pigment epithelium (RPE) - Bruch's Membrane (BM) complex in the 1 mm central circle (Hazard ratio (HR)= 1.13 for 1 μm increase; P(FDR)= 8.08 x 10(-4)). Incident advanced AMD was associated with thicker RPE-BM complex in both the central circle (HR= 1.09; P(FDR)= 0.005) and the inner circle (1 mm - 3 mm) (HR= 1.28; P(FDR)= 1.61 x 10(-5)). Over the study period, RPE-BM complex thickening in the inner circle was more pronounced in individuals with high total PRS (ß= 0.06 μm/year for 1 standard deviation increase, P(FDR)= 1.61 x 10(-10)), high complement pathway PRS (ß= 0.04 μm/year, P(FDR)=3.23 x 10(-5)), high lipid pathway PRS (ß= 0.03 μm/year, P(FDR)= 3.74 x 10(-4)) and ARMS2 (ß= 0.03 μm/year, P(FDR)= 0.002). Further, high total PRS and high complement-specific PRS were associated with thinner photoreceptor segment layer (PSL) at baseline and with thinning of the outer nuclear layer over the study period. CONCLUSION: These results highlight the importance of RPE-BM complex thickening in the pathophysiological sequence of AMD. Further longitudinal studies are needed, in particular to determine the value of RPE-BM thickening and PSL thinning measured using SD-OCT for the clinical follow-up of AMD patients. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | OCT | |
| dc.subject.en | Clinical (Human) Or Epidemiologic Studies: Polygenic Risk Score | |
| dc.subject.en | Genetic Risk | |
| dc.subject.en | Imaging | |
| dc.title.en | Neuroretinal and RPE changes and susceptibility to Age-Related Macular Degeneration: insights from the longitudinal Alienor Study | |
| dc.title.alternative | Ophthalmology | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.ophtha.2025.01.002 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 39793657 | en_US |
| bordeaux.journal | Ophthalmology: Journal of The American Academy of Ophthalmology | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04956673 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-02-19T12:59:34Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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