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Thermoresponsive polymer brush-functionalized magnetic manganite nanoparticles for remotely triggered drug release

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hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLOUGUET, Stéphanie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorROUSSEAU, Bérengère
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorEPHERRE, Romain
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorGUIDOLIN, Nicolas
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorGOGLIO, Graziella
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stephane
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, Etienne
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2012
dc.identifier.issn1759-9954
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20499
dc.description.abstractEnA thermoresponsive hybrid system for drug delivery purposes is designed by modifying the surface of silica-coated magnetic lanthanum strontium manganite nanoparticles with block copolymers following a non-covalent approach. Block copolymers containing a short poly(L-lysine) segment and a polyether segment of varying composition are adsorbed through electrostatic interactions between positively charged lysine units and negatively charged SiO− groups at the silica surface, giving rise to mixed polyether brushes with a good control over the chain surface density and thickness of the polymer layer. The thermoresponsiveness of the assemblies is controlled by the ethylene oxide/propylene oxide ratio in the polymer brush and the corresponding LCST of the polyether blocks. Important parameters like the aggregation temperature of the particles can be finely adjusted by modifying this ratio. The polarity of the polymer layer can also be varied to maximize the encapsulation efficiency of a moderately hydrophobic drug like doxorubicin. Drug release experiments are performed by taking advantage of the ac magnetically induced heating properties of the magnetic core to speed up the release of doxorubicin owing to structural changes within the polyether brush.
dc.language.isoen
dc.publisherRoyal Society of Chemistry - RSC
dc.subject.enMagnetism
dc.subject.enPolymer
dc.subject.enThermoresponsive brush
dc.subject.enDrug
dc.subject.enManganite
dc.title.enThermoresponsive polymer brush-functionalized magnetic manganite nanoparticles for remotely triggered drug release
dc.typeArticle de revue
dc.identifier.doi10.1039/C2PY20089A
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
bordeaux.journalPolymer Chemistry
bordeaux.page1408-1417
bordeaux.volume3
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue6
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00700504
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00700504v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Polymer%20Chemistry&rft.date=2012&rft.volume=3&rft.issue=6&rft.spage=1408-1417&rft.epage=1408-1417&rft.eissn=1759-9954&rft.issn=1759-9954&rft.au=LOUGUET,%20St%C3%A9phanie&ROUSSEAU,%20B%C3%A9reng%C3%A8re&EPHERRE,%20Romain&GUIDOLIN,%20Nicolas&GOGLIO,%20Graziella&rft.genre=article


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