Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy
dc.rights.license | open | |
hal.structure.identifier | THEME 2 | |
dc.contributor.author | SANSON, Charles | |
hal.structure.identifier | THEME 2 | |
dc.contributor.author | DIOU, Odile | |
hal.structure.identifier | THEME 2 | |
dc.contributor.author | THEVENOT, Julie | |
hal.structure.identifier | THEME 2 | |
dc.contributor.author | IBARBOURE, Emmanuel | |
hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
dc.contributor.author | SOUM, Alain | |
hal.structure.identifier | Laboratoire Léon Brillouin [LLB - UMR 12] | |
dc.contributor.author | BRÛLET, Annie | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | MIRAUX, Sylvain | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | THIAUDIÈRE, Eric | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | TAN, Sisareuth | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | BRISSON, Alain | |
hal.structure.identifier | Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques [PECSA] | |
dc.contributor.author | DUPUIS, Vincent | |
hal.structure.identifier | THEME 2 | |
dc.contributor.author | SANDRE, Olivier | |
hal.structure.identifier | THEME 2 | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.created | 2011 | |
dc.date.issued | 2012 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20496 | |
dc.description.abstractEn | Hydrophobically modified magnetic nanoparticles (MNPs) were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formulation method provides a high loading of MNPs (up to 70 wt %) together with a good control over the sizes of the vesicles (100 - 400 nm). The deformation of the vesicle membrane under an applied magnetic field was evidenced by anisotropic SANS. These hybrid objects display contrast enhancement properties in Magnetic Resonance Imaging, a diagnostic method routinely used for three-dimensional and non-invasive scans of the human body. They can also be guided in a magnetic field gradient. The feasibility of drug release triggered by magnetic induction was evidenced using the anticancer drug doxorubicin (DOX), which is co-encapsulated in the membrane. Magnetic polymersomes are thus proposed as multimodal drug nanocarriers for bio-imaging and magneto-chemotherapy. | |
dc.language.iso | en | |
dc.title.en | Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy | |
dc.type | Article de revue | |
dc.subject.hal | Chimie/Matériaux | |
dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft] | |
dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci] | |
dc.identifier.arxiv | 1209.5098 | |
dc.description.sponsorshipEurope | FP7 CP-IP 213631-2 NANOTHER | |
bordeaux.journal | LLB Highlights 2011 | |
bordeaux.page | 48-49 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | non | |
hal.identifier | hal-00734562 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00734562v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=LLB%20Highlights%202011&rft.date=2012&rft.spage=48-49&rft.epage=48-49&rft.au=SANSON,%20Charles&DIOU,%20Odile&THEVENOT,%20Julie&IBARBOURE,%20Emmanuel&SOUM,%20Alain&rft.genre=article |
Fichier(s) constituant ce document
Fichiers | Taille | Format | Vue |
---|---|---|---|
Il n'y a pas de fichiers associés à ce document. |