THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | GIRAUD, Julie | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | CHALOPIN, Domitille | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | RAMEL, Eloïse | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | BOYER, Thomas | |
| dc.contributor.author | ZOUINE, Atika | |
| dc.contributor.author | DERIEPPE, Marie-Alix | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | LARMONIER, Nicolas
IDREF: 07942581X | |
| dc.contributor.author | ADOTEVI, Olivier | |
| dc.contributor.author | LE BAIL, Brigitte | |
| dc.contributor.author | BLANC, Jean-Frédéric | |
| dc.contributor.author | LAURENT, Christophe | |
| dc.contributor.author | CHICHE, Laurence | |
| dc.contributor.author | DERIVE, Marc | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | NIKOLSKI, Macha
IDREF: 134506049 | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | SALEH, Maya | |
| dc.date.accessioned | 2025-02-10T14:46:15Z | |
| dc.date.available | 2025-02-10T14:46:15Z | |
| dc.date.issued | 2024-02 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/204782 | |
| dc.description.abstractEn | Hepatocellular carcinoma (HCC) is an inflammation-associated cancer arising from viral or non-viral etiologies including steatotic liver diseases (SLDs). Expansion of immunosuppressive myeloid cells is a hallmark of inflammation and cancer, but their heterogeneity in HCC is not fully resolved and might underlie immunotherapy resistance. Here, we present a high-resolution atlas of innate immune cells from patients with HCC that unravels an SLD-associated contexture characterized by influx of inflammatory and immunosuppressive myeloid cells, including a discrete population of THBS1+ regulatory myeloid (Mreg) cells expressing monocyte- and neutrophil-affiliated genes. THBS1+ Mreg cells expand in SLD-associated HCC, populate fibrotic lesions, and are associated with poor prognosis. THBS1+ Mreg cells are CD163+ but distinguished from macrophages by high expression of triggering receptor expressed on myeloid cells 1 (TREM1), which contributes to their immunosuppressive activity and promotes HCC tumor growth in vivo. Our data support myeloid subset-targeted immunotherapies to treat HCC. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Liver cancer | |
| dc.subject.en | Steatohepatitis | |
| dc.subject.en | Immunotherapy | |
| dc.subject.en | Innate immunity | |
| dc.subject.en | Myeloid cells | |
| dc.subject.en | TREM1 | |
| dc.subject.en | Inflammation | |
| dc.subject.en | Hepatocellular carcinoma | |
| dc.subject.en | Metabolism | |
| dc.title.en | THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1 | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.celrep.2024.113773 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 38350444 | en_US |
| bordeaux.journal | Cell Reports | en_US |
| bordeaux.volume | 43 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2024-02&rft.volume=43&rft.issue=2&rft.au=GIRAUD,%20Julie&CHALOPIN,%20Domitille&RAMEL,%20Elo%C3%AFse&BOYER,%20Thomas&ZOUINE,%20Atika&rft.genre=article |