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The Conceptual Definition of Sarcopenia: Delphi Consensus from the Global Leadership Initiative in Sarcopenia (GLIS)

dc.rights.licenseopenen_US
dc.contributor.authorKIRK, Ben
dc.contributor.authorCAWTHON, Peggy M
dc.contributor.authorARAI, Hidenori
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAVILA-FUNES, Jose Alberto
dc.contributor.authorBARAZZONI, Rocco
dc.contributor.authorBHASIN, Shalender
dc.contributor.authorBINDER, Ellen F
dc.contributor.authorBRUYERE, Olivier
dc.contributor.authorCEDERHOLM, Tommy
dc.contributor.authorCHEN, Liang-Kung
dc.contributor.authorCOOPER, Cyrus
dc.contributor.authorDUQUE, Gustavo
dc.contributor.authorFIELDING, Roger A
dc.contributor.authorGURALNIK, Jack
dc.contributor.authorKIEL, Douglas P
dc.contributor.authorLANDI, Francesco
dc.contributor.authorREGINSTER, Jean-Yves
dc.contributor.authorSAYER, Avan A
dc.contributor.authorVISSER, Marjolein
dc.contributor.authorVON HAEHLING, Stephan
dc.contributor.authorWOO, Jean
dc.contributor.authorCRUZ-JENTOFT, Alfonso J
dc.date.accessioned2025-02-10T12:09:00Z
dc.date.available2025-02-10T12:09:00Z
dc.date.issued2024-03-01
dc.identifier.issn1468-2834en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204778
dc.description.abstractEnSarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on the definition exists. The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing the global conceptual definition of sarcopenia. The GLIS steering committee was formed in 2019-21 with representatives from all relevant scientific societies worldwide. During this time, the steering committee developed a set of statements on the topic and invited members from these societies to participate in a two-phase International Delphi Study. Between 2022 and 2023, participants ranked their agreement with a set of statements using an online survey tool (SurveyMonkey). Statements were categorised based on predefined thresholds: strong agreement (>80%), moderate agreement (70-80%) and low agreement (<70%). Statements with strong agreement were accepted, statements with low agreement were rejected and those with moderate agreement were reintroduced until consensus was reached. 107 participants (mean age: 54 ± 12 years [1 missing age], 64% men) from 29 countries across 7 continents/regions completed the Delphi survey. Twenty statements were found to have a strong agreement. These included; 6 statements on 'general aspects of sarcopenia' (strongest agreement: the prevalence of sarcopenia increases with age (98.3%)), 3 statements on 'components of sarcopenia' (muscle mass (89.4%), muscle strength (93.1%) and muscle-specific strength (80.8%) should all be a part of the conceptual definition of sarcopenia)) and 11 statements on 'outcomes of sarcopenia' (strongest agreement: sarcopenia increases the risk of impaired physical performance (97.9%)). A key finding of the Delphi survey was that muscle mass, muscle strength and muscle-specific strength were all accepted as 'components of sarcopenia', whereas impaired physical performance was accepted as an 'outcome' rather than a 'component' of sarcopenia. The GLIS has created the first global conceptual definition of sarcopenia, which will now serve to develop an operational definition for clinical and research settings.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enMale
dc.subject.enHumans
dc.subject.enAged
dc.subject.enFemale
dc.subject.enSarcopenia
dc.subject.enDelphi Technique
dc.subject.enConsensus
dc.subject.enLeadership
dc.subject.enMuscle Strength
dc.title.enThe Conceptual Definition of Sarcopenia: Delphi Consensus from the Global Leadership Initiative in Sarcopenia (GLIS)
dc.title.alternativeAge Ageingen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ageing/afae052en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38520141en_US
bordeaux.journalAge and Ageingen_US
bordeaux.pageafae052en_US
bordeaux.volume53en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04938140
hal.version1
hal.date.transferred2025-02-10T12:09:04Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Age%20and%20Ageing&amp;rft.date=2024-03-01&amp;rft.volume=53&amp;rft.issue=3&amp;rft.spage=afae052&amp;rft.epage=afae052&amp;rft.eissn=1468-2834&amp;rft.issn=1468-2834&amp;rft.au=KIRK,%20Ben&amp;CAWTHON,%20Peggy%20M&amp;ARAI,%20Hidenori&amp;AVILA-FUNES,%20Jose%20Alberto&amp;BARAZZONI,%20Rocco&amp;rft.genre=article


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