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Dietary patterns of polyphenols and risk of advanced age-related macular degeneration: the Alienor study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMERLE, Benedicte
ORCID: 0000-0003-1332-0954
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDIAW, Mody
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPELLAY, Hermine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBARDINET, Jeanne
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
ORCID: 0000-0002-7959-1610
IDREF: 08195848X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELYFER, Marie-Noelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535
IDREF: 028739272
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
dc.date.accessioned2025-02-06T08:30:09Z
dc.date.available2025-02-06T08:30:09Z
dc.date.issued2024-06-01
dc.date.conference2024-05-05
dc.identifier.issn0146-0404en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204729
dc.description.abstractEnPurpose : A high adherence to a Mediterranean diet, characterized by a high consumption of fruits, vegetables and olive oil, is associated with a lower risk of AMD. These foods are rich in polyphenols (PPs), which have antioxidant and anti-inflammatory properties and could help reduce the onset and progression of AMD. We report the associations between dietary intake of PPs and the incidence of advanced AMD in French older adults. Methods : The Alienor study is an ongoing population-based cohort of 963 elderly residents of Bordeaux followed every 2-year since 2006. AMD was classified from color fundus photographs and SD-OCT (2006-17), and using self-reported AMD (2001-06). Dietary intakes of PPs were estimated from a 24-hour dietary recall (2001) using the Phenol-Explorer database. Principal component analysis (PCA) was used to extract PPs patterns from the 21 PPs families. Associations between PPs patterns and families and incidence of advanced AMD were assessed by Cox proportional hazards models adjusted for age, sex, total energy intake, smoking status, marital status, physical activity and education. Results : Among 862 participants eligible for these analyses, 100 (11.6%) developed advanced AMD. Three patterns of PPs were identified: pattern 1 characterized by high consumption of stilbenes, hydroxybenzaldehydes, dihydroflavonols and lignans; pattern 2 by high consumption of hydroxycinnamic acids, alkylmethoxyphenols and other PPs; and pattern 3 by high consumption of alkylmethoxyphenols, catechins, hydroxycinnamic acids and theaflavins. After adjustment, none of the pattern was significantly associated with advanced AMD (hazard ratio (HR)=1.05, 95% confidence interval (95%CI) [0.94-1.17]; HR=1.10, 95%CI [0.97-1.26]; HR=1.06, 95%CI [0.91-1.23], respectively). A higher intake of hydroxycinnamic acids was positively associated with advanced AMD (Q2 HR=2.17 95%CI [1.13-4.16]; Q3 HR=2.14 95%CI [1.10-4.15]; Q4 HR=1.95 95%CI [0.99-3.83] vs. Q1) and a higher intake of catechins was negatively associated with advanced AMD (Q2 HR=0.49 95%CI [0.28-0.87]; Q3 HR=0.49 95%CI [0.28-0.87]; Q4 HR=0.63 95%CI [0.37-1.08] vs. Q1). Conclusions : In this study, no association was found between patterns of PPs and incidence of advanced AMD. However, high consumption of hydroxycinnamic acids (coffee) was associated with an increased risk of AMD, and high consumption of catechins (tea) with a lower risk of AMD.
dc.language.isoENen_US
dc.title.enDietary patterns of polyphenols and risk of advanced age-related macular degeneration: the Alienor study
dc.typeCommunication dans un congrèsen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.volume65en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.conference.title2024 ARVO Annual Meetingen_US
bordeaux.countryusen_US
bordeaux.title.proceedingInvestigative Ophthalmology & Visual Scienceen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.conference.citySeattleen_US
hal.identifierhal-04931847
hal.version1
hal.date.transferred2025-02-06T08:30:13Z
hal.proceedingsouien_US
hal.conference.organizerARVOen_US
hal.conference.end2024-05-09
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2024-06-01&rft.volume=65&rft.issue=7&rft.eissn=0146-0404&rft.issn=0146-0404&rft.au=MERLE,%20Benedicte&DIAW,%20Mody&PELLAY,%20Hermine&BARDINET,%20Jeanne&SAMIERI,%20Cecilia&rft.genre=unknown


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