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Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19

dc.rights.licenseopenen_US
dc.contributor.authorDALLAN, Beatrice
dc.contributor.authorPROIETTO, Davide
dc.contributor.authorDE LAURENTIS, Martina
dc.contributor.authorGALLERANI, Eleonora
dc.contributor.authorMARTINO, Mara
dc.contributor.authorGHISELLINI, Sara
dc.contributor.authorZURLO, Amedeo
dc.contributor.authorVOLPATO, Stefano
dc.contributor.authorGOVONI, Benedetta
dc.contributor.authorBORGHESI, Michela
dc.contributor.authorALBANESE, Valentina
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorAPPAY, Victor
dc.contributor.authorBONNINI, Stefano
dc.contributor.authorLLEWELLYN-LACEY, Sian
dc.contributor.authorPACIFICO, Salvatore
dc.contributor.authorGRUMIRO, Laura
dc.contributor.authorBRANDOLINI, Martina
dc.contributor.authorSEMPRINI, Simona
dc.contributor.authorSAMBRI, Vittorio
dc.contributor.authorLADELL, Kristin
dc.contributor.authorPARRY, Helen M.
dc.contributor.authorMOSS, Paul A. H.
dc.contributor.authorPRICE, David A.
dc.contributor.authorBARBIERI, Elena
dc.contributor.authorBERNARDI, Tatiana
dc.contributor.authorBONI, Michela
dc.contributor.authorDALL’OLIO, Linda
dc.contributor.authorDE LAURENTIS, Martina
dc.contributor.authorFIORINI, Caterina
dc.contributor.authorFIORINI, Michele
dc.contributor.authorGOVONI, Maurizio
dc.contributor.authorNERI, Margherita
dc.contributor.authorPALMA, Fabio
dc.contributor.authorROMAGNONI, Franco
dc.contributor.authorCAPUTO, Antonella
dc.contributor.authorGAVIOLI, Riccardo
dc.contributor.authorNICOLI, Francesco
dc.date.accessioned2025-02-03T13:07:12Z
dc.date.available2025-02-03T13:07:12Z
dc.date.issued2024-06
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204702
dc.description.abstractEnAdenoviral and mRNA vaccines encoding the viral spike (S) protein have been deployed globally to contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older individuals are particularly vulnerable to severe infection, probably reflecting age-related changes in the immune system, which can also compromise vaccine efficacy. It is nonetheless unclear to what extent different vaccine platforms are impacted by immunosenescence. Here, we evaluated S protein-specific immune responses elicited by vaccination with two doses of BNT162b2 or ChAdOx1-S and subsequently boosted with a single dose of BNT162b2 or mRNA-1273, comparing age-stratified participants with no evidence of previous infection with SARS-CoV-2. We found that aging profoundly compromised S protein-specific IgG titers and further limited S protein-specific CD4+ and CD8+ T cell immunity as a probable function of progressive erosion of the naive lymphocyte pool in individuals vaccinated initially with BNT162b2. Our results demonstrate that primary vaccination with ChAdOx1-S and subsequent boosting with BNT162b2 or mRNA-1273 promotes sustained immunological memory in older adults and potentially confers optimal protection against coronavirus disease 2019.
dc.language.isoENen_US
dc.title.enAge differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s43587-024-00644-wen_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed38918602en_US
bordeaux.journalNature Agingen_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04926727
hal.version1
hal.date.transferred2025-02-03T13:07:18Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Aging&rft.date=2024-06&rft.au=DALLAN,%20Beatrice&PROIETTO,%20Davide&DE%20LAURENTIS,%20Martina&GALLERANI,%20Eleonora&MARTINO,%20Mara&rft.genre=article


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