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Working-life exposome and new-onset COPD: An exposome-wide association study (ExWAS)

dc.rights.licenseopenen_US
dc.contributor.authorMOELLER KYNDE, Theresa
dc.contributor.authorWAN, Wenxin
dc.contributor.authorGARCIA, Judith
dc.contributor.authorALCARAZ, Victoria
dc.contributor.authorURRUTIA, Isabelines
dc.contributor.authorMARTINEZ-MORATALLA, Jesus
dc.contributor.authorPALACIOS GOMEZ, Leopoldo
dc.contributor.authorSHEIKH, Alif
dc.contributor.authorLODGE, Caroline
dc.contributor.authorBENKE, Geza
dc.contributor.authorBENTOUHAMI, Hayat
dc.contributor.authorCASAS RUIZ, Lidia
dc.contributor.authorLYTRAS, Theodore
dc.contributor.authorLEYNAERT, Bénédicte
dc.contributor.authorDEMOLY, Pascal
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON, Chantal
dc.contributor.authorSIROUX, Valerie
dc.contributor.authorGOLDBERG, Marcel
dc.contributor.authorDUMAS, Orianne
dc.contributor.authorNADIF, Rachel
dc.contributor.authorLEMOUAL, Nicole
dc.contributor.authorGÍSLASON, Torarin
dc.contributor.authorKIERKELEIT, Jorunn
dc.contributor.authorSVANES, Cecilie
dc.contributor.authorJANSON, Christer
dc.contributor.authorHOLM, Mathias
dc.contributor.authorMODIG, Lars
dc.contributor.authorKROMHOUT, Hans
dc.contributor.authorPRONK, Anjoeka
dc.contributor.authorPORTENGEN, Lûtzen
dc.contributor.authorPETERS, Susan
dc.contributor.authorZOCK, Jan-Paul
dc.contributor.authorJARVIS, Debbie
dc.contributor.authorLUND WÜRTZ, Anne Mette
dc.contributor.authorKOLSTAD, Henrik Albert
dc.contributor.authorSCHLÜNSSEN, Vivi
dc.date.accessioned2025-01-30T12:42:13Z
dc.date.available2025-01-30T12:42:13Z
dc.date.issued2024-09-01
dc.date.conference2024-09-07
dc.identifier.issn0903-1936en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204661
dc.description.abstractEnIntroduction: COPD is a leading cause of death worldwide and linked to occupational exposures. We aimed to explore the link between working-life exposome and new-onset COPD, starting with an exposome-wide association study (ExWAS). Method: We included two European multi-centre population-based cohorts, ECRHS and Constances. ECRHS began in 1992 (participants 20-44 years) with two follow-ups at ~10 and ~20 years. Constances, baseline 2012-2020 (18-69 years), one follow-up at ~4 years. COPD was defined by FEV1/FVC<Lower limit of normal and at least one respiratory symptom, excluding those with COPD at baseline. Cumulative exposure was assessed at each follow-up for 49 occupational exposures using 5 job exposure matrices. The ExWAS was conducted with discrete-time hazard models adjusted for sex, weight, pack-years of smoking, parental asthma, years between follow-up, physical activity and center. Results: Information was available for n=4065, male 51% (ECRHS) and n=5855, male 49% (Constances). In ECRHS we found increased risk of new-onset COPD (adjusted Odds ratios; 95% CI) for exposure to: exhaust fumes (1.12; 1.03-1.21), asbestos (1.13; 1.02-1.24), gas fumes (1.13; 1.1-1.25), biological dust (1.11; 1.0-1.22), heavy lifting (1.13; 1.0-1.25), mineral dust (1.11; 1.0-1.23), and house dust mites (1.07; 1.0-1-15). There was no evidence for effect-modification by asthma status. No clear associations were found for Constances. Conclusion: Occupational exposures was linked to increased risk of COPD in ECRHS only, probably due to an older population and longer time of follow-up compared to Constances. This ExWAS set the stage for the next analytical step, assessing the joint effect of the working life-exposme.
dc.language.isoENen_US
dc.title.enWorking-life exposome and new-onset COPD: An exposome-wide association study (ExWAS)
dc.typeCommunication dans un congrèsen_US
dc.identifier.doi10.1183/13993003.congress-2024.oa974en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.pageOA974en_US
bordeaux.volume64en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issuesuppl. 68en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.conference.titleThe ERS Congress 2024en_US
bordeaux.countryaten_US
bordeaux.title.proceedingEuropean Respiratory Journalen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.conference.cityVienneen_US
bordeaux.import.sourcecrossref
hal.identifierhal-04921049
hal.version1
hal.date.transferred2025-01-30T12:42:18Z
hal.proceedingsouien_US
hal.conference.end2024-09-11
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcecrossref
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.date=2024-09-01&amp;rft.volume=64&amp;rft.issue=suppl.%2068&amp;rft.spage=OA974&amp;rft.epage=OA974&amp;rft.eissn=0903-1936&amp;rft.issn=0903-1936&amp;rft.au=MOELLER%20KYNDE,%20Theresa&amp;WAN,%20Wenxin&amp;GARCIA,%20Judith&amp;ALCARAZ,%20Victoria&amp;URRUTIA,%20Isabelines&amp;rft.genre=unknown


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