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Profiles of the maternal occupational exposome during pregnancy and associations with intrauterine growth: analysis of the French Longitudinal Study of Children – ELFE study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTARTAGLIA, Marie
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorCOSTET, Nathalie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAUDIGNON-DURAND, Sabyne
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCARLES, Camille
hal.structure.identifierCentre Hospitalier Universitaire d'Angers [CHU Angers]
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
hal.structure.identifierDonald and Barbara Zucker School of Medicine at Hofstra/Northwell [Hempstead, NY, USA]
dc.contributor.authorD'ESCATHA, Alexis
hal.structure.identifierKarolinska Institute
dc.contributor.authorFALKSTEDT, Daniel
dc.contributor.authorHOUOT, Marie-Tülin
hal.structure.identifierKarolinska Institute
dc.contributor.authorKJELLBERG, Katarina
hal.structure.identifierSanté publique France - French National Public Health Agency [Saint-Maurice, France]
dc.contributor.authorPILORGET, Corinne
hal.structure.identifierRadboud University [Nijmegen]
dc.contributor.authorROELEVELD, Nel
hal.structure.identifierUniversité de Montréal [UdeM]
dc.contributor.authorSIEMIATYCKI, Jack
hal.structure.identifierInstituto de Salud Global - Institute For Global Health [Barcelona] [ISGlobal]
dc.contributor.authorTURNER, Michelle C.
hal.structure.identifierInstituto de Salud Global - Institute For Global Health [Barcelona] [ISGlobal]
dc.contributor.authorTURUBAN, Maxime
hal.structure.identifierFinnish Institute of Occupational Health of Helsinki [FIOH]
dc.contributor.authorUUKSULAINEN, Sanni
hal.structure.identifierEtude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) [ELFE]
dc.contributor.authorDUFOURG, Marie Noelle
hal.structure.identifierCentre Hospitalier Universitaire [Rennes]
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorGARLANTÉZEC, Ronan
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierCentre Hospitalier Universitaire d'Angers [CHU Angers]
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorDELVA, Fleur
dc.date.accessioned2025-01-28T11:21:04Z
dc.date.available2025-01-28T11:21:04Z
dc.date.issued2025-02-15
dc.identifier.issn0013-9351en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204622
dc.description.abstractEnBackground: Numerous agents in the workplace are suspected of impairing fetal growth. To date, no epidemiological studies have specifically described the occupational exposome during pregnancy.Objective: The objectives were to determine maternal occupational exposome profiles and study their associations with intrauterine growth characteristics measured by small for gestational age (SGA), birthweight (BW), and head circumference (HC).Methods: We used data from the French national ELFE cohort. Occupational exposures to 47 agents (chemical, physical, biological, biomechanical, organizational and psychosocial), were identified using job exposure matrices. Mothers were classified as occupationally not exposed, uncertainly exposed, or exposed depending on their probability of exposure. Outcomes of interest were BW, SGA and HC. Maternal profiles of the occupational exposome were determined using hierarchical clustering of principal components. Associations between profiles and intrauterine growth outcomes were studied using linear or logistic regression models adjusted for potential confounders. Analyses were carried out depending on whether mothers stopped working during pregnancy.Results: The 12,851 included women were exposed to a median of 6 factors. Four occupational exposome profiles were identified, characterized by \"low exposure, stress at work\"; \"strenuous, high organization, low decision\"; \"postural constraints, psychosocial factors\", \"postural and strength constraints, chemical and biological factors\". In multivariate analyses, and among women who stopped working during the third trimester of pregnancy, analyses found associations between the profile \"postural constraints, psychosocial factor\" and SGA, and HC. None of the other exposure profiles were statistically significantly associated with foetal growth outcomes.Conclusion: The results show that the specific profile \"postural constraints, psychosocial factors\" may increase the risk of foetal growth retardation. Although these results need to be replicated, this study provides a first better understanding of the exposome of pregnant women at the workplace which may help to better adapt prevention strategies.
dc.description.sponsorshipPlateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - ANR-11-EQPX-0038en_US
dc.description.sponsorshipResarch platform on cohorts of children followed from birth - ANR-19-COHO-0001en_US
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enBirthweight
dc.subject.enHead circumference
dc.subject.enMulti-exposure
dc.subject.enOccupational exposome
dc.subject.enPregnancy
dc.subject.enSmall for gestational age
dc.title.enProfiles of the maternal occupational exposome during pregnancy and associations with intrauterine growth: analysis of the French Longitudinal Study of Children – ELFE study
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envres.2024.120669en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed39710240en_US
bordeaux.journalEnvironmental Researchen_US
bordeaux.page120669en_US
bordeaux.volume267en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04870799
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Research&rft.date=2025-02-15&rft.volume=267&rft.spage=120669&rft.epage=120669&rft.eissn=0013-9351&rft.issn=0013-9351&rft.au=TARTAGLIA,%20Marie&COSTET,%20Nathalie&AUDIGNON-DURAND,%20Sabyne&CARLES,%20Camille&D'ESCATHA,%20Alexis&rft.genre=article


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