Easy and effective method to produce functionalized particles for cellular uptake
dc.rights.license | open | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
dc.contributor.author | COLLETTE, Floraine | |
hal.structure.identifier | Synthèse et réactivité des substances naturelles [UMR 6514] [SRSN [Poitiers]] | |
dc.contributor.author | DELATOUCHE, Régis | |
hal.structure.identifier | Centre de Recherche en Cancérologie Nantes-Angers [CRCNA] | |
dc.contributor.author | BLANQUART, Christophe | |
hal.structure.identifier | Centre de Recherche en Cancérologie Nantes-Angers [CRCNA] | |
dc.contributor.author | GUEUGNON, Fabien | |
hal.structure.identifier | Centre de Recherche en Cancérologie Nantes-Angers [CRCNA] | |
dc.contributor.author | GREGOIRE, Marc | |
hal.structure.identifier | Synthèse et réactivité des substances naturelles [UMR 6514] [SRSN [Poitiers]] | |
dc.contributor.author | BERTRAND, Philippe | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 1 LCPO : Polymerization Catalyses & Engineering | |
dc.contributor.author | HÉROGUEZ, Valérie | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0887-624X | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20461 | |
dc.description.abstractEn | In this contribution, a versatile approach for the synthesis of functionalized particles for drug delivery is presented, using two nonaggressive standardized procedures. The first procedure considered is the functionalization of an azido-terminated α-norbornenyl poly(ethylene oxide) (PEO) macromonomer with an alkyne-containing active molecule via the copper catalyzed azide alkyne cycloaddition, click type reaction. The functionalized macromonomer is then polymerized by Ring-Opening Metathesis Polymerization (ROMP) in dispersion to form functionalized particles. The second procedure consists in synthesizing particles by ROMP in dispersed media of norbornene with azido-terminated α-norbornenyl PEO macromonomer. The ROMP was initiated by the first generation Grubbs catalyst. Such functionalized core-shell particles have stealthy properties due to their PEO shell and can be viewed as universal nanocarriers on which any alkyne-modified active molecule can be grafted by click chemistry. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013 | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.subject.en | poly(ethylene oxide) | |
dc.subject.en | core-shell particles | |
dc.subject.en | click chemistry | |
dc.subject.en | biocompatibility | |
dc.subject.en | polynorbornene | |
dc.subject.en | ROMP | |
dc.title.en | Easy and effective method to produce functionalized particles for cellular uptake | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1002/pola.26357 | |
dc.subject.hal | Chimie/Polymères | |
bordeaux.journal | Journal of Polymer Science Part A: Polymer Chemistry | |
bordeaux.page | 176-189 | |
bordeaux.volume | 51 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 1 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00758913 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00758913v1 | |
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