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Molecular Xenomonitoring (MX) allows real-time surveillance of West Nile and Usutu virus in mosquito populations

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBIGEARD, Clément
dc.contributor.authorPEZZI, Laura
dc.contributor.authorKLITTING, Raphaelle
dc.contributor.authorAYHAN, Nazli
dc.contributor.authorL'AMBERT, Grégory
dc.contributor.authorGOMEZ, Nicolas
dc.contributor.authorPIORKOWSKI, Géraldine
dc.contributor.authorAMARAL, Rayane
dc.contributor.authorDURAND, Guillaume André
dc.contributor.authorCOLMANT, Agathe M G
dc.contributor.authorGIRAUD, Cynthia
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorRAMIARA, Katia
dc.contributor.authorMIGNÉ, Camille
dc.contributor.authorGRARD, Gilda
dc.contributor.authorTOUZET, Thierry
dc.contributor.authorZIENTARA, Stéphan
dc.contributor.authorCHARREL, Rémi
dc.contributor.authorGONZALEZ, Gaëlle
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorDUVIGNAUD, Alexandre
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorMALVY, Denis
dc.contributor.authorDE LAMBALLERIE, Xavier
dc.contributor.authorFONTAINE, Albin
dc.date.accessioned2025-01-28T09:53:20Z
dc.date.available2025-01-28T09:53:20Z
dc.date.issued2024-12-01
dc.identifier.issn1935-2735en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204615
dc.description.abstractEnWest Nile Virus (WNV) and Usutu virus (USUV) circulate through complex cryptic transmission cycles involving mosquitoes as vectors, birds as amplifying hosts and several mammal species as dead-end hosts. Both viruses can be transmitted to humans through mosquito bites, which can lead to neuroinvasive and potentially fatal disease. Notably, WNV can also be transmitted through blood donations and organ transplants. The high proportion of asymptomatic infections caused by these viruses and their cryptic enzootic circulation make their early detection in the environment challenging. Viral surveillance in France still heavily relies on human and animal surveillance, i.e. late indicators of viral circulation. Entomological surveillance is a method of choice for identifying virus circulation ahead of the first human and animal cases and to reveal their genetic identity, but performing molecular screening of vectors is expensive, and time-consuming. Here we show substantial WNV and USUV co-circulation in Atlantic seaboard of France between July and August 2023 using a non-invasive MX (Molecular Xenomonitoring) method that use trapped mosquito excreta. MX offers significant advantages over traditional entomological surveillance: it is cost-effective and efficient, enabling viral RNA screening from a community of trapped mosquitoes via their excreta, which can be transported at room temperature. Additionally, MX extends the longevity of trapped mosquitoes, enhancing virus detection and simplifying logistics, and is easy to implement without requiring specialized skills. At the crossroads between entomological and environmental surveillance, MX can detect the circulation of zoonotic pathogens in the environment before cases are observed in humans and horses, enabling the timely alerts to health policy makers, allowing them to take suitable control measures.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAnimals
dc.subject.enWest Nile virus
dc.subject.enFlavivirus
dc.subject.enFrance
dc.subject.enMosquito Vectors
dc.subject.enFlavivirus Infections
dc.subject.enWest Nile Fever
dc.subject.enCulicidae
dc.subject.enHumans
dc.subject.enRNA
dc.subject.enViral
dc.subject.enEpidemiological Monitoring
dc.title.enMolecular Xenomonitoring (MX) allows real-time surveillance of West Nile and Usutu virus in mosquito populations
dc.title.alternativePLoS Negl Trop Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pntd.0012754en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39724146en_US
bordeaux.journalPLoS Neglected Tropical Diseasesen_US
bordeaux.pagee0012754en_US
bordeaux.volume18en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
bordeaux.identifier.funderIDDirection Générale de l’Armementen_US
bordeaux.identifier.funderIDMinistère de l'Agriculture, de l'Agroalimentaire et de la Forêten_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04916194
hal.version1
hal.date.transferred2025-01-28T09:53:24Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
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