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The in vivo behavior and antitumor activity of doxorubicin-loaded poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes in Ehrlich ascites tumor-bearing BalB/c mice

dc.rights.licenseopen
hal.structure.identifierPharm Dept, Fac Technol & Eng, Univ Baroda
dc.contributor.authorUPADHYAY, Kamal Kumar
hal.structure.identifierDiv Cyclotron & Radiopharmaceut Sci [DRDO, INMAS]
dc.contributor.authorMISHRA, Anil Kumar
hal.structure.identifierDiv Cyclotron & Radiopharmaceut Sci [DRDO, INMAS]
dc.contributor.authorCHUTTANI, Krishna
hal.structure.identifierDiv Cyclotron & Radiopharmaceut Sci [DRDO, INMAS]
dc.contributor.authorKAUL, Ankur
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
hal.structure.identifierPharm Dept, Fac Technol & Eng, Univ Baroda
dc.contributor.authorMISRA, Ambikanandan
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2012
dc.identifier.issn1549-9634
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20449
dc.description.abstractEnThe in vivo efficacy of doxorubicin (DOX)-loaded poly(gamma-benzyl L-glutamate)-block-hyaluronan (PBLG(23)-b-HYA(10))-based polymersomes (PolyDOX) was evaluated. Samples were efficiently labeled with technetium-99m radionuclide with good stability for in vivo studies. PolyDOX enhanced circulation time compared to free DOX. Biodistribution studies revealed selective accumulation of PolyDOX in the Ehrlich ascites tumor (EAT) as a result of passive accumulation and active targeting (CD44-mediated endocytosis) in EAT-bearing mice. Toxicity studies demonstrated PolyDOX is a safe drug carrier, and no hemolysis was observed with PolyDOX equivalent to 200 mu g/mL of free DOX. PolyDOX dominantly controlled tumor growth by delaying doubling time of EATs compared to free DOX over 30 days after treatment. PolyDOX also increased life span six times more than free DOX. Hence, it is reasonable to expect that higher DOX levels attributable to PolyDOX improve the therapeutic index and reduce side effects due to site-specific drug accumulation.
dc.language.isoen
dc.publisherElsevier
dc.subject.enDoxorubicin
dc.subject.enHyaluronan
dc.subject.enPolymersomes
dc.subject.enEhrlich ascites tumor (EAT)
dc.subject.enAntitumor activity
dc.title.enThe in vivo behavior and antitumor activity of doxorubicin-loaded poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes in Ehrlich ascites tumor-bearing BalB/c mice
dc.typeArticle de revue
dc.identifier.doi10.1016/j.nano.2011.05.008
dc.subject.halChimie/Polymères
bordeaux.journalNanomedicine: Nanotechnology, Biology and Medicine
bordeaux.page71-80
bordeaux.volume8
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue1
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00805018
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00805018v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nanomedicine:%20Nanotechnology,%20Biology%20and%20Medicine&rft.date=2012&rft.volume=8&rft.issue=1&rft.spage=71-80&rft.epage=71-80&rft.eissn=1549-9634&rft.issn=1549-9634&rft.au=UPADHYAY,%20Kamal%20Kumar&MISHRA,%20Anil%20Kumar&CHUTTANI,%20Krishna&KAUL,%20Ankur&SCHATZ,%20Christophe&rft.genre=article


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