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Biocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity

dc.rights.licenseopen
hal.structure.identifierGAIKER Technological Centre
dc.contributor.authorGONI-DE-CERIO, Felipe
hal.structure.identifierTev Aviv Univ, Sackler Sch Med
dc.contributor.authorMARIANI, Valentina
hal.structure.identifierAhava Dead Sea Laboratories
hal.structure.identifierDead Sea-Arava Science Center [DSASC]
dc.contributor.authorCOHEN, Dror
hal.structure.identifierTev Aviv Univ, Sackler Sch Med
dc.contributor.authorMADI, Lea
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorTHEVENOT, Julie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorDE OLIVEIRA, Hugo
hal.structure.identifierJRC Institute for Health and Consumer Protection [IHCP]
dc.contributor.authorUBOLDI, Chiara
hal.structure.identifierJRC Institute for Health and Consumer Protection [IHCP]
dc.contributor.authorGIUDETTI, Guido
hal.structure.identifierJRC Institute for Health and Consumer Protection [IHCP]
dc.contributor.authorCORADEGHINI, Rosella
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierJRC Institute for Health and Consumer Protection [IHCP]
dc.contributor.authorROSSI, François
hal.structure.identifierAhava Dead Sea Laboratories
dc.contributor.authorPORTUGAL-COHEN, Meital
hal.structure.identifierAhava Dead Sea Laboratories
dc.contributor.authorORON, Miriam
hal.structure.identifierTev Aviv Univ, Sackler Sch Med
dc.contributor.authorKORENSTEIN, Rafi
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierJRC Institute for Health and Consumer Protection [IHCP]
dc.contributor.authorPONTI, Jessica
hal.structure.identifierGAIKER Technological Centre
dc.contributor.authorSUAREZ-MERINO, Blanca
hal.structure.identifierGAIKER Technological Centre
dc.contributor.authorHEREDIA, Pedro
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2013
dc.identifier.issn1388-0764
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20395
dc.description.abstractEnDrugs used for chemotherapy normally carry out adverse, undesired effects. Nanotechnology brings about new horizons to tackle cancer disease with a different strategy. One of the most promising approaches is the use of nanocarriers to transport active drugs. These nanocarriers need to have special properties to avoid immune responses and toxicity, and it is critical to study these effects. Nanocarriers may have different nature, but polypeptide-based copolymers have attracted considerable attention for their biocompatibility, controlled and slow biodegradability as well as low toxicity. Little has been done regarding specific nanocarriers toxicity. In this study, we performed a thorough toxicological study of two different block copolymer nanoparticles (NPs); poly(trimethylene carbonate)-block-poly(L-glutamic acid) (PTMC-b-PGA) and poly(ethylene glycol)-block-poly(gamma-benzyl-L-glutamate) (PEG-b-PBLG) with sizes between 113 and 131 nm. Low blood-serum-protein interaction was observed. Moreover, general toxicity assays and other endpoints (apoptosis or necrosis) showed good biocompatibility for both NPs. Reactive oxygen species increased in only two cell lines (HepG2 and TK6) in the presence of PTMC-b-PGA. Cytokine production study showed cytokine induction only in one cell line (A549). We also performed the same assays on human skin organ culture before and after UVB light treatment, with a moderate toxicity after treatment independent of NPs presence or absence. Interleukin 1 induction was also observed due to the combined effect of PEG-b-PBLG and UVB light irradiation. Future in vivo studies for biocompatibility and toxicity will provide more valuable information, but, so far, the findings presented here suggest the possibility of using these two NPs as nanocarriers for nanomedical applications, always taking into account the application procedure and the way in which they are implemented.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enAmphiphilic copolymers
dc.subject.enNanoparticles
dc.subject.enIn vitro toxicity
dc.subject.enCancer therapy
dc.subject.enNanoparticles toxicity
dc.subject.enBiomedicine
dc.title.enBiocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity
dc.typeArticle de revue
dc.identifier.doi10.1007/s11051-013-2036-0
dc.subject.halChimie/Polymères
bordeaux.journalJournal of Nanoparticle Research
bordeaux.page1-17, UNSP 2036
bordeaux.volume15
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue11
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00926508
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00926508v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Nanoparticle%20Research&rft.date=2013&rft.volume=15&rft.issue=11&rft.spage=1-17,%20UNSP%202036&rft.epage=1-17,%20UNSP%202036&rft.eissn=1388-0764&rft.issn=1388-0764&rft.au=GONI-DE-CERIO,%20Felipe&MARIANI,%20Valentina&COHEN,%20Dror&MADI,%20Lea&THEVENOT,%20Julie&rft.genre=article


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