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Baseline characteristics of the first 302 patients included for acute malignant hypertension crisis in the prospective multidisciplinary HAMA cohort.

dc.rights.licenseopenen_US
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorBOULESTREAU, Romain
dc.contributor.authorLORTHIOIR, Aurélien
dc.contributor.authorDREAU, Hervé
dc.contributor.authorPERSU, Alexandre
dc.contributor.authorCREMER, Antoine
dc.contributor.authorTHARAUX, Pierre-Louis
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorRUBIN, Sébastien
dc.contributor.authorMAIER, Benjamin
dc.contributor.authorMAZIGHI, Mikael
dc.contributor.authorSERIS, Alice
dc.contributor.authorPAQUES, Michel
dc.contributor.authorBONNIN, Sophie
dc.contributor.authorHALIMI, Jean Michel
dc.contributor.authorDEBEUGNY, Stéphane
dc.contributor.authorGOSSE, Philippe
dc.date.accessioned2024-12-09T10:59:33Z
dc.date.available2024-12-09T10:59:33Z
dc.date.issued2024-12-01
dc.identifier.issn1473-5598en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203795
dc.description.abstractEnMalignant hypertension has not disappeared and remains the most severe form of hypertension. More than 100 years after its description, many points remain unanswered. Mechanisms, definitions, and optimal treatment are still controversial. In 2019, we decided to launch a prospective multicentre multidisciplinary cohort in France to try to fill these gaps. This study aimed to describe the baseline characteristics of the first 302 included patients and compared these data to already published cohorts. We included patients with severe hypertension associated with severe hypertensive retinopathy and patients filling the HYP MOD (HYPertension MultiOrgan Damage) definition from a broad range of departments (cardiology, nephrology, neurology intensive care unit, emergency department, internal medicine). We collected clinical, biological, imaging, and target organ damage data at admission, along with social and demographic data. We also recorded diagnostic and therapeutic management, adverse events during hospitalization, and characteristics at discharge. We enrolled 302 patients in 32 months (105/year) among 40 centres and different specialties. They mainly included young men (68%, mean age 48.7 ± 14.5 years). Target organ damage involved the eye in 86.7% of patients, kidney in 58.6%, heart in 50%, brain in 32.8%, and Thrombotic Microangiopathy stigmata in 15.6%. Patients with severe retinopathy shared characteristics similar to those included in the most important cohorts already published. We also reported several additional subgroups of interest: one-third of our patients were less than 40 years old, one-third were of non-European origin, 14.3% were included through the multiorgan damage definition, without fundus severe injuries, 22.8% were treated without the use of IV therapy, 40.9% had normal or low renin level, and almost all patients were not on antihypertensive therapy at the time of the enrolment. These preliminary findings already challenge long-standing dogma, raise numerous questions, and provide a solid basis to address them in ancillary studies of the cohort.
dc.language.isoENen_US
dc.subject.enHumans
dc.subject.enMale
dc.subject.enMiddle Aged
dc.subject.enFemale
dc.subject.enHypertension
dc.subject.enMalignant
dc.subject.enProspective Studies
dc.subject.enAdult
dc.subject.enFrance
dc.subject.enAged
dc.subject.enHypertensive Retinopathy
dc.subject.enCohort Studies
dc.subject.enAcute Disease
dc.subject.enAntihypertensive Agents
dc.title.enBaseline characteristics of the first 302 patients included for acute malignant hypertension crisis in the prospective multidisciplinary HAMA cohort.
dc.title.alternativeJ Hypertensen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/HJH.0000000000003851en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed39351849en_US
bordeaux.journalJournal of Hypertensionen_US
bordeaux.page2131-2138en_US
bordeaux.volume42en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04826697
hal.version1
hal.date.transferred2024-12-09T10:59:36Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Hypertension&rft.date=2024-12-01&rft.volume=42&rft.issue=12&rft.spage=2131-2138&rft.epage=2131-2138&rft.eissn=1473-5598&rft.issn=1473-5598&rft.au=BOULESTREAU,%20Romain&LORTHIOIR,%20Aur%C3%A9lien&DREAU,%20Herv%C3%A9&PERSU,%20Alexandre&CREMER,%20Antoine&rft.genre=article


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