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Course of brain damage following malignant hypertension.

dc.rights.licenseopenen_US
dc.contributor.authorLIEGEY, Jean Sebastien
dc.contributor.authorCREMER, Antoine
dc.contributor.authorLUCAS, Ludovic
dc.contributor.authorGOSSE, Philippe
dc.contributor.authorDEBEUGNY, Stéphane
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorRUBIN, Sebastien
dc.contributor.authorDOUBLET, Julien
dc.contributor.authorSIBON, Igor
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorBOULESTREAU, Romain
dc.date.accessioned2024-12-09T10:47:20Z
dc.date.available2024-12-09T10:47:20Z
dc.date.issued2024-11-01
dc.identifier.issn1476-5527en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203793
dc.description.abstractEnMalignant hypertension (MHT) crisis triggers widespread microvascular damage, particularly in the brain. Despite recent MRI evidence highlighting acute cerebral injuries during MHT crises, follow-up data remain scarce. This study seeks to fill this gap by exploring how brain MRI markers evolve following acute MHT crisis management. We conducted a retrospective analysis of brain MRI data from MHT patients admitted to Bordeaux University Hospital between 2008 and 2022. Eligible patients had at least one follow-up MRI. Analysis blinded to clinical data was performed to identify markers of posterior reversible encephalopathy syndrome (PRES), acute stroke, cerebral hemorrhage, and microangiopathy. Out of 149 patients, 47 had follow-up MRIs. Most were male (72.3%) with a mean age of 48.2 ± 10.8 years. The median interval between initial and follow-up MRI was 228 days. Follow-up MRIs revealed new strokes in 10.6% of patients, cerebral hemorrhages in 4.3%, and no cases of PRES. Additionally, more patients exhibited chronic lacunar infarcts and/or microbleeds, with overall Fazekas scores remaining stable in 66.0%, improving in 31.9%, and worsening in 2.1%. Subgroup analyses based on blood pressure control or follow-up duration showed no significant differences in MRI markers. This study sheds light on the risk of new cerebrovascular events and the dynamic changes in brain MRI markers following acute MHT crisis management. Understanding these changes could lead to improved diagnosis, personalized treatment strategies, and proactive patient care for individuals with MHT.
dc.language.isoENen_US
dc.title.enCourse of brain damage following malignant hypertension.
dc.title.alternativeJ Hum Hypertensen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41371-024-00968-5en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed39487319en_US
bordeaux.journalJournal of Human Hypertensionen_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04826646
hal.version1
hal.date.transferred2024-12-09T10:47:23Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Human%20Hypertension&rft.date=2024-11-01&rft.eissn=1476-5527&rft.issn=1476-5527&rft.au=LIEGEY,%20Jean%20Sebastien&CREMER,%20Antoine&LUCAS,%20Ludovic&GOSSE,%20Philippe&DEBEUGNY,%20St%C3%A9phane&rft.genre=article


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