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Course of immune thrombocytopenia according to the site of platelet destruction identified by indium-111 platelet scintigraphy.

dc.rights.licenseopenen_US
dc.contributor.authorDURAND, Pauline
dc.contributor.authorPOTTIER, Valérie
dc.contributor.authorDEBORDEAUX, Frédéric
dc.contributor.authorMESGUICH, Charles
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorDUFFAU, Pierre
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorLAZARO, Estibaliz
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorVIALLARD, Jean-François
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorRIVIÈRE, Etienne
dc.date.accessioned2024-12-09T10:35:32Z
dc.date.available2024-12-09T10:35:32Z
dc.date.issued2024-10-15
dc.identifier.issn1365-2141en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203790
dc.description.abstractEnIn primary immune thrombocytopenia (ITP), predictors of disease evolution and treatment response are needed. Data based on the site of platelet destruction are scarce. We performed a retrospective single-centre study of adult patients with primary ITP undergoing at least one Indium-111 platelet scintigraphy (IPS) between 2009 and 2018. Thirty-three patients had isolated hepatic platelet destruction (H-group), and 97 isolated splenic destruction (S-group). Median age at diagnosis (p < 0.001), proportion of associated cardiovascular (p < 0.001), organ-specific autoimmune diseases (p = 0.02), dependence on steroids (p = 0.003) and failure to rituximab (p = 0.01) were higher and relapse more frequent (p = 0.03) in H-group compared to non-splenectomized patients in S-group. Splenectomy was only performed in patients from S-group (as patients with hepatic sequestration are not splenectomized in our centre): 79% were in relapse-free remission at the end of a median 3.4-year post-IPS follow-up, 16% relapsed. In multivariate analyses, only a history of organ-specific autoimmune or inflammatory disease was significantly associated with hepatic sequestration (OR = 4.3, 95% CI = 1.2-15, p = 0.02). Patients with isolated hepatic sequestration were older, had more cardiovascular events and organ-specific autoimmune diseases, greater dependence on steroids, more relapses and a decreased response rate to rituximab suggesting an increased refractoriness to immunomodulatory therapies. Patients with isolated splenic sequestration responded well to splenectomy.
dc.language.isoENen_US
dc.subject.enTPO receptor agonists; immune thrombocytopenia; indium‐111 platelet scintigraphy; rituximab; sequestration pattern; splenectomy
dc.title.enCourse of immune thrombocytopenia according to the site of platelet destruction identified by indium-111 platelet scintigraphy.
dc.title.alternativeBr J Haematolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/bjh.19833en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed39407432en_US
bordeaux.journalBritish Journal of Haematologyen_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04826600
hal.version1
hal.date.transferred2024-12-09T10:35:34Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=British%20Journal%20of%20Haematology&amp;rft.date=2024-10-15&amp;rft.eissn=1365-2141&amp;rft.issn=1365-2141&amp;rft.au=DURAND,%20Pauline&amp;POTTIER,%20Val%C3%A9rie&amp;DEBORDEAUX,%20Fr%C3%A9d%C3%A9ric&amp;MESGUICH,%20Charles&amp;DUFFAU,%20Pierre&amp;rft.genre=article


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