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Viral whole genome sequencing reveals high variations in APOBEC3 editing between HPV risk categories

dc.rights.licenseopenen_US
dc.contributor.authorFERRE, Valentine Marie
dc.contributor.authorCOPPEE, Romain
dc.contributor.authorGBEASOR-KOMLANVI, Fifonsi A
dc.contributor.authorVACHER, Sophie
dc.contributor.authorBRIDIER-NAHMIAS, Antoine
dc.contributor.authorBUCAU, Margot
dc.contributor.authorSALOU, Mounerou
dc.contributor.authorLAMEIRAS, Sonia
dc.contributor.authorCOUVELARD, Anne
dc.contributor.authorDAGNRA, Anoumou Claver
dc.contributor.authorBIECHE, Ivan
dc.contributor.authorDESCAMPS, Diane
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorEKOUEVI, Didier Koumavi
dc.contributor.authorGHOSN, Jade
dc.contributor.authorCHARPENTIER, Charlotte
dc.date.accessioned2024-12-06T10:06:51Z
dc.date.available2024-12-06T10:06:51Z
dc.date.issued2024-10-01
dc.identifier.issn1096-9071en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203729
dc.description.abstractEnHigh-risk human papillomavirus (HPV) infections are responsible for cervical cancer. However, little is known about the differences between HPV types and risk categories regarding their genetic diversity and particularly APOBEC3-induced mutations - which contribute to the innate immune response to HPV. Using a capture-based next-generation sequencing, 156 HPV whole genome sequences covering 43 HPV types were generated from paired cervical and anal swabs of 30 Togolese female sex workers (FSWs) sampled in 2017. Genetic diversity and APOBEC3-induced mutations were assessed at the viral whole genome and gene levels. Thirty-four pairwise sequence comparisons covering 24 HPV types in cervical and anal swabs revealed identical infections in the two anatomical sites. Differences in genetic diversity among HPV types was observed between patients. The E6 gene was significantly less conserved in low-risk HPVs (lrHPVs) compared to high-risk HPVs (hrHPVs) (p = 0.009). APOBEC3-induced mutations were found to be more common in lrHPVs than in hrHPVs (p = 0.005), supported by our data and by using large HPV sequence collections from the GenBank database. Focusing on the most common lrHPVs 6 and 11 and hrHPVs 16 and 18, APOBEC3-induced mutations were predominantly found in the E4 and E6 genes in lrHPVs, but were almost absent in these genes in hrHPVs. The variable APOBEC3 mutational signatures could contribute to the different oncogenic potentials between HPVs. Further studies are needed to conclusively determine whether APOBEC3 editing levels are associated to the carcinogenic potential of HPVs at the type and sublineage scales.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAPOBEC3
dc.subject.enAnal
dc.subject.enCervical
dc.subject.enGenetic Diversity
dc.subject.enHuman Papillomavirus
dc.subject.enWhole Genome
dc.title.enViral whole genome sequencing reveals high variations in APOBEC3 editing between HPV risk categories
dc.title.alternativeJ Med Virolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/jmv.70002en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39400339en_US
bordeaux.journalJournal of Medical Virologyen_US
bordeaux.pagee70002en_US
bordeaux.volume96en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
hal.identifierhal-04822820
hal.version1
hal.date.transferred2024-12-06T10:06:54Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Medical%20Virology&rft.date=2024-10-01&rft.volume=96&rft.issue=10&rft.spage=e70002&rft.epage=e70002&rft.eissn=1096-9071&rft.issn=1096-9071&rft.au=FERRE,%20Valentine%20Marie&COPPEE,%20Romain&GBEASOR-KOMLANVI,%20Fifonsi%20A&VACHER,%20Sophie&BRIDIER-NAHMIAS,%20Antoine&rft.genre=article


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