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Clozapine and objective assessment of hypersomnolence in patients with schizophrenia: a systematic review

dc.rights.licenseopenen_US
dc.contributor.authorQUILES, Clélia
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorTAILLARD, Jacques
ORCID: 0000-0001-9067-8189
IDREF: 229930786
dc.contributor.authorLOPEZ, Régis
dc.contributor.authorGEOFFROY, Pierre Alexis
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSALVO, Francesco
IDREF: 221043470
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorMICOULAUD FRANCHI, Jean Arthur
IDREF: 199759170
dc.date.accessioned2024-11-21T10:13:10Z
dc.date.available2024-11-21T10:13:10Z
dc.date.issued2024-10-30
dc.identifier.issn1365-2869en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203399
dc.description.abstractEnClozapine is effective in treatment-resistant schizophrenia but with adverse effects including sedation. Excessive daytime sleepiness, a symptom of hypersomnolence, is the most frequently reported subjective side-effect. The aim of this systematic review was to synthesise the literature evaluating the impact of clozapine on the objective assessment of hypersomnolence in people with schizophrenia. We systematically searched databases for articles evaluating hypersomnolence with electrophysiological or psychomotor/cognitive measures in clozapine-treated patients with schizophrenia. Objective assessment of hypersomnolence was evaluated in six studies. All studies using polysomnography (PSG) found significantly longer total sleep time and shorter sleep onset latency in patients treated with clozapine at initiation of clozapine. The study with the multiple sleep latency test (MSLT) also found a shorter sleep onset latency. These observations did not persist 4-6 weeks after treatment initiation. Further investigations are needed. Longer total sleep time should be investigated with standardised long-term PSG to investigate excessive sleep quantity. Shorter sleep onset latency should be investigated with the MSLT or the maintenance of wakefulness test to investigate the excessive propensity to fall asleep or ability to stay awake. Lastly, sleep inertia should be investigated specifically in the morning.
dc.language.isoENen_US
dc.subject.enClozapine
dc.subject.enDrowsiness
dc.subject.enMaintenance Of Wakefulness Test (MWT)
dc.subject.enMultiple Sleep Latency Test (MSLT)
dc.subject.enPolysomnography (PSG)
dc.subject.enSleepiness
dc.title.enClozapine and objective assessment of hypersomnolence in patients with schizophrenia: a systematic review
dc.title.alternativeJ Sleep Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/jsr.14360en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39478127en_US
bordeaux.journalJournal of Sleep Researchen_US
bordeaux.pagee14360en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04795145
hal.version1
hal.date.transferred2024-11-21T10:13:14Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Sleep%20Research&rft.date=2024-10-30&rft.spage=e14360&rft.epage=e14360&rft.eissn=1365-2869&rft.issn=1365-2869&rft.au=QUILES,%20Cl%C3%A9lia&TAILLARD,%20Jacques&LOPEZ,%20R%C3%A9gis&GEOFFROY,%20Pierre%20Alexis&SALVO,%20Francesco&rft.genre=article


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