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Neutral genetic structuring of pathogen populations during rapid adaptation

hal.structure.identifierInteractions Arbres-Microorganismes [IAM]
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
hal.structure.identifierTechnische Universität Munchen - Technical University Munich - Université Technique de Munich [TUM]
dc.contributor.authorSAUBIN, Méline
hal.structure.identifierDynamique et durabilité des écosystèmes : de la source à l’océan [DECOD]
hal.structure.identifierInstitut de Génétique, Environnement et Protection des Plantes [IGEPP]
dc.contributor.authorSTOECKEL, Solenn
hal.structure.identifierTechnische Universität Munchen - Technical University Munich - Université Technique de Munich [TUM]
dc.contributor.authorTELLIER, Aurélien
hal.structure.identifierInteractions Arbres-Microorganismes [IAM]
dc.contributor.authorHALKETT, Fabien
dc.date2024-11-17
dc.date.issued2024-11-17
dc.identifier.issn0022-1503
dc.description.abstractEnPathogen species are experiencing strong joint demographic and selective events, especially when they adapt to a new host, for example through overcoming plant resistance. Stochasticity in the founding event and the associated demographic variations hinder our understanding of the expected evolutionary trajectories and the genetic structure emerging at both neutral and selected loci. What would be the typical genetic signatures of such a rapid adaptation event is not elucidated. Here, we build a demogenetic model to monitor pathogen population dynamics and genetic evolution on two host compartments (susceptible and resistant). We design our model to fit two plant pathogen life cycles, “with” and “without” host alternation. Our aim is to draw a typology of eco-evolutionary dynamics. Using time-series clustering, we identify three main scenarios: 1) small variations in the pathogen population size and small changes in genetic structure, 2) a strong founder event on the resistant host that in turn leads to the emergence of genetic structure on the susceptible host, and 3) evolutionary rescue that results in a strong founder event on the resistant host, preceded by a bottleneck on the susceptible host. We pinpoint differences between life cycles with notably more evolutionary rescue “with” host alternation. Beyond the selective event itself, the demographic trajectory imposes specific changes in the genetic structure of the pathogen population. Most of these genetic changes are transient, with a signature of resistance overcoming that vanishes within a few years only. Considering time-series is therefore of utmost importance to accurately decipher pathogen evolution.
dc.description.sponsorshipLes conséquences génétiques de reproduction partiellement clonale dans les populations colonisant de nouveaux territoires - ANR-18-CE32-0001
dc.description.sponsorshipPour une durabilité accrue envers les ennemis des cultures - ANR-23-CE20-0032
dc.description.sponsorshipRecherches Avancées sur l'Arbre et les Ecosytèmes Forestiers - ANR-11-LABX-0002
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subject.encomplex life cycles
dc.subject.enforward demogenetic model
dc.subject.enhost adaptation
dc.subject.enplant pathogen
dc.subject.enpopulation genetic structure
dc.subject.entime-series clustering
dc.title.enNeutral genetic structuring of pathogen populations during rapid adaptation
dc.typeArticle de revue
dc.identifier.doi10.1093/jhered/esae036
dc.subject.halSciences de l'environnement
bordeaux.journalJournal of Heredity
bordeaux.peerReviewedoui
hal.identifierhal-04792713
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04792713v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Heredity&rft.date=2024-11-17&rft.eissn=0022-1503&rft.issn=0022-1503&rft.au=SAUBIN,%20M%C3%A9line&STOECKEL,%20Solenn&TELLIER,%20Aur%C3%A9lien&HALKETT,%20Fabien&rft.genre=article


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