Droplet Microfluidics to Prepare Magnetic Polymer Vesicles and to Confine the Heat in Magnetic Hyperthermia
| dc.rights.license | open | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | HABAULT, Damien | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | DERY, Alexandre | |
| dc.contributor.author | LENG, Jacques | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LE MEINS, Jean-Francois | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | SANDRE, Olivier | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.issued | 2013 | |
| dc.identifier.issn | 0018-9464 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20333 | |
| dc.description.abstractEn | In this work, we present two types of microfluidic chips involving magnetic nanoparticles dispersed in cyclohexane with oleic acid. In the first case, the hydrophobically coated nanoparticles are self-assembled with an amphiphilic diblock copolymer by a double-emulsion process in order to prepare giant magnetic vesicles (polymersomes) in one step and at a high throughput. It was shown in literature that such diblock copolymer W/O/Wemulsion droplets can evolve into polymersomes made of a thin (nanometric) magnetic membrane through a dewetting transition of the oil phase from the aqueous internal cores usually leading to "acorn-like" structures (polymer excess) sticking to the membranes. To address this issue and greatly speed up the process, the solvent removal by evaporation was replaced by a "shearing-off" of the vesicles in a simple poly(dimethylsiloxane) chip designed to exert a balance between a magnetic gradient and viscous shear. In the second example, a simple oil-in-oil emulsion chip is used to obtain regular trains of magnetic droplets that circulate inside an inductor coil producing a radio-frequency magnetic field. We evidence that the heat produced by magnetic hyperthermia can be converted into a temperature rise even at the scale of nL droplets. The results are compared to heat transfer models in two limiting cases: adiabatic vs. dissipative. The aim is to decipher the delicate puzzle about the minimum size required for a tumor "phantom" to be heated by radio-frequency hyperthermia in a general scope of anticancer therapy. | |
| dc.language.iso | en | |
| dc.publisher | Institute of Electrical and Electronics Engineers | |
| dc.subject.en | self-assembly | |
| dc.subject.en | microfluidics | |
| dc.subject.en | magnetophoresis | |
| dc.subject.en | magnetic hyperthermia | |
| dc.subject.en | soft magnetic materials | |
| dc.subject.en | Heat transfer | |
| dc.title.en | Droplet Microfluidics to Prepare Magnetic Polymer Vesicles and to Confine the Heat in Magnetic Hyperthermia | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1109/TMAG.2012.2221688 | |
| dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft] | |
| dc.subject.hal | Chimie/Polymères | |
| dc.subject.hal | Chimie/Matériaux | |
| dc.identifier.arxiv | 1209.5249 | |
| bordeaux.journal | IEEE Transactions on Magnetics | |
| bordeaux.page | 182-190, Part 2 | |
| bordeaux.volume | 49 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 1 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00959604 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00959604v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=IEEE%20Transactions%20on%20Magnetics&rft.date=2013&rft.volume=49&rft.issue=1&rft.spage=182-190,%20Part%202&rft.epage=182-190,%20Part%202&rft.eissn=0018-9464&rft.issn=0018-9464&rft.au=HABAULT,%20Damien&DERY,%20Alexandre&LENG,%20Jacques&LECOMMANDOUX,%20Sebastien&LE%20MEINS,%20Jean-Francois&rft.genre=article |
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