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Giant cell arteritis associated with scalp, tongue or lip necrosis: A French multicenter case control study

dc.rights.licenseopenen_US
dc.contributor.authorCHEHEM DAOUD CHEHEM, Ferida
dc.contributor.authorDE MORNAC, Donatienne
dc.contributor.authorFEUILLET, Fanny
dc.contributor.authorLIOZON, Eric
dc.contributor.authorSAMSON, Maxime
dc.contributor.authorBONNOTTE, Bernard
dc.contributor.authorDE BOYSSON, Hubert
dc.contributor.authorGUFFROY, Aurélien
dc.contributor.authorBALQUET, Marie-Hélène
dc.contributor.authorLEDOULT, Emmanuel
dc.contributor.authorLAVIGNE, Christian
dc.contributor.authorTREFOND, Ludovic
dc.contributor.authorSMETS, Perrine
dc.contributor.authorBODARD, Quentin
dc.contributor.authorFENOT, Marion
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorRICHEZ, Christophe
dc.contributor.authorDUFFAU, Pierre
dc.contributor.authorGUILLAUD, Constance
dc.contributor.authorESPITIA, Olivier
dc.contributor.authorAGARD, Christian
dc.date.accessioned2024-11-07T12:32:45Z
dc.date.available2024-11-07T12:32:45Z
dc.date.issued2024-02
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203160
dc.description.abstractEnBackground: Scalp, tongue and/or lip necrosis are rare complications of GCA. Objectives: To describe characteristics and outcome of patients with giant cell arteritis (GCA) -related scalp, tongue and/or lip necrosis. Methods: A retrospective nationwide multicenter study included 20 GCA patients with scalp, tongue, and/or lip necrosis diagnosed between 1998 and 2021 and 80 GCA control patients matched for age, sex and management period. Logistic regression analyses were conducted to identify baseline characteristics associated with scalp, tongue and/or lip necrosis. Results: Compared to controls, patients with scalp, tongue and/or lip necrosis showed significantly more cranial manifestations (headache, p=0.045; scalp tenderness, p=0.006; jaw claudication, p=0.02). No differences were observed between both groups regarding the occurrence of visual symptoms or large vessel involvement. At diagnosis, GCA patients with necrosis more likely received IV methylprednisolone infusions and higher doses of oral prednisone. There were no differences regarding vascular complications during follow up. Compared to controls, survival was decreased in GCA patients with necrosis (p=0.003). In a multivariable logistic regression model, scalp tenderness [odds ratio (OR) 4.81(95 % CI: 1.57, 14.79), p = 0.006] and cognitive disorder [OR 6.42 (95 % CI: 1.01, 40.60), p=0.048] were identified as factors associated to scalp, tongue, and/or lip necrosis. Conclusion: Our results suggest that scalp, tongue, and/or lip necrosis is associated to higher mortality in GCA patients. Scalp tenderness and cognitive disorder were significant factors associated to this very rare complication of GCA
dc.language.isoENen_US
dc.subject.enGiant-cell arteritis
dc.subject.enScalp necrosis
dc.subject.enTongue necrosis
dc.subject.enLip necrosis
dc.title.enGiant cell arteritis associated with scalp, tongue or lip necrosis: A French multicenter case control study
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.semarthrit.2023.152348en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed38091870en_US
bordeaux.journalSeminars in Arthritis and Rheumatismen_US
bordeaux.volume64en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04771401
hal.version1
hal.date.transferred2024-11-07T12:32:48Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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