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Trends in epidemiology and risk factors of opportunistic infections in kidney transplant recipients between 2004 and 2017

dc.rights.licenseopenen_US
dc.contributor.authorPFIRMANN, Pierre
dc.contributor.authorGARRIGUE, Isabelle
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCHAUVEAU, Bertrand
dc.contributor.authorRONDEAU, Virginie
ORCID: 0000-0001-7109-4831
IDREF: 16662988X
dc.contributor.authorTUMIOTTO, Camille
dc.contributor.authorWEINMANN, Laurent
dc.contributor.authorDUBOIS, Véronique
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorMERVILLE, Pierre
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorKAMINSKI, Hannah
dc.contributor.authorTATON, Benjamin
dc.date.accessioned2024-11-07T10:53:24Z
dc.date.available2024-11-07T10:53:24Z
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203159
dc.description.abstractEnBackground. While opportunistic infections are a frequent and challenging problem in kidney transplant recipients, their long-term epidemiology remains hardly known. Methods. Opportunistic infections were recorded in 1144 recipients transplanted in our center between 2004 and 2015. Incidence rates and baseline risk factors were determined using joint frailty models. Results. After a median follow-up of 5.6 years, 544 opportunistic infections occurred in 373/1144 (33%) patients, dominated by viral infections (396/544, 72%), especially cytomegalovirus (CMV) syndromes and diseases (213/544, 39%). One-third of the infected patients experienced at least two opportunistic infections. The incidence of opportunistic infections was 10 times higher during the first year post-transplantation than after that (34.7 infections for 100 patient-years vs 3.64). Opportunistic infections associated with the age of the donor (P = .032), the age of the recipient (P = .049), the CMV serostatus (P < 10−6), a higher class II HLA mismatch (P = .032) and an induction treatment including rabbit anti-thymocyte globulins (P = .026). Repeated opportunistic infections associated with each other (P < 10−6) and with renal death (P < 10−6). Conclusion. Opportunistic infections occur with a two-period incidence pattern and many susceptible patients suffer from repeated episodes. This knowledge may help tailor new prevention and follow-up strategies to reduce the burden of opportunistic infections and their impact on transplantation outcome.
dc.language.isoENen_US
dc.subject.enEpidemiology
dc.subject.enImmunosuppression
dc.subject.enKidney transplantation
dc.subject.enOpportunistic infection
dc.subject.enPrognosis
dc.title.enTrends in epidemiology and risk factors of opportunistic infections in kidney transplant recipients between 2004 and 2017
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ndt/gfad193en_US
dc.identifier.pubmed37667539en_US
bordeaux.journalNephrology Dialysis Transplantationen_US
bordeaux.page627 – 636en_US
bordeaux.volume39en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
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dc.rights.ccPas de Licence CCen_US
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