Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy
dc.rights.license | open | |
hal.structure.identifier | Synthèse organique [E5 – IC2MP équipe 5] [OrgaSynth] | |
dc.contributor.author | DELATOUCHE, R. | |
hal.structure.identifier | Université de Nantes [UN] | |
hal.structure.identifier | Centre de Recherche en Cancérologie Nantes-Angers [CRCNA] | |
dc.contributor.author | DENIS, I. | |
hal.structure.identifier | Synthèse organique [E5 – IC2MP équipe 5] [OrgaSynth] | |
dc.contributor.author | GRINDA, M. | |
hal.structure.identifier | Synthèse organique [E5 – IC2MP équipe 5] [OrgaSynth] | |
dc.contributor.author | EL BAHHAJ, F. | |
hal.structure.identifier | Centre de Recherche en Cancérologie Nantes-Angers [CRCNA] | |
hal.structure.identifier | Université de Nantes [UN] | |
dc.contributor.author | BAUCHER, E. | |
hal.structure.identifier | THEME 1A | |
dc.contributor.author | COLLETTE, F. | |
hal.structure.identifier | THEME 1A | |
dc.contributor.author | HÉROGUEZ, V. | |
hal.structure.identifier | Centre de Recherche en Cancérologie Nantes-Angers [CRCNA] | |
hal.structure.identifier | Université de Nantes [UN] | |
dc.contributor.author | GREGOIRE, M. | |
hal.structure.identifier | Centre de Recherche en Cancérologie Nantes-Angers [CRCNA] | |
hal.structure.identifier | Université de Nantes [UN] | |
dc.contributor.author | BLANQUART, C. | |
hal.structure.identifier | Synthèse organique [E5 – IC2MP équipe 5] [OrgaSynth] | |
dc.contributor.author | BERTRAND, P. | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0939-6411 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20314 | |
dc.description.abstractEn | The aim of this study was to develop clickable prodrugs bearing a tunable pH responsive linker designed for acidic pH-mediated release of histone deacetylase inhibitors. HDACi are an important class of molecules belonging to the epigenetic modulators used for innovative cancer strategies. The behavior of these prodrugs was determined by a bioluminescence resonance energy transfer assay in living tumor cells. This work demonstrated that this innovative type of clickable prodrugs entered cancer cells and showed restored anti proliferative properties attributed to the effective release of the HDAC inhibitors. A correlation between kinetic studies, dose responses, and biological activities was obtained, making such clickable prodrugs good candidates for new strategies in epigenetic-oriented anticancer therapies | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.title.en | Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1016/j.ejpb.2013.03.006 | |
dc.subject.hal | Chimie/Catalyse | |
dc.subject.hal | Chimie/Chimie organique | |
dc.subject.hal | Chimie/Autre | |
bordeaux.journal | European Journal of Pharmaceutics and Biopharmaceutics | |
bordeaux.page | 862-872 B | |
bordeaux.volume | 85 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 3 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01006764 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01006764v1 | |
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