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Concordance and agreement between different activity scores in polymyalgia rheumatica

dc.rights.licenseopenen_US
dc.contributor.authorD'AGOSTINO, Justine
dc.contributor.authorSOUKI, Aghiles
dc.contributor.authorLOHSE, Anne
dc.contributor.authorCARVAJAL ALEGRIA, Guillermo
dc.contributor.authorDERNIS, Emanuelle
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorRICHEZ, Christophe
dc.contributor.authorTRUCHETET, Marie-Elise
dc.contributor.authorWENDLING, Daniel
dc.contributor.authorTOUSSIROT, Eric
dc.contributor.authorPERDRIGER, Aleth
dc.contributor.authorGOTTENBERG, Jacques-Eric
dc.contributor.authorFELTEN, Renaud
dc.contributor.authorFAUTREL, Bruno
dc.contributor.authorCHICHE, Laurent
dc.contributor.authorHILLIQUIN, Pascal
dc.contributor.authorLE HENAFF, Catherine
dc.contributor.authorDERVIEUX, Benjamin
dc.contributor.authorDIREZ, Guillaume
dc.contributor.authorCHARY-VALCKENAERE, Isabelle
dc.contributor.authorCORNEC, Divi
dc.contributor.authorGUELLEC, Dewi
dc.contributor.authorMARHADOUR, Thierry
dc.contributor.authorNOWAK, Emmanuel
dc.contributor.authorSARAUX, Alain
dc.contributor.authorDEVAUCHELLE-PENSEC, Valérie
dc.date.accessioned2024-11-06T14:50:02Z
dc.date.available2024-11-06T14:50:02Z
dc.date.issued2024
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203147
dc.description.abstractEnObjective The C reactive protein polymyalgia rheumatica activity score (CRP-PMR-AS) is a composite index that includes CRP levels and was developed specifically for PMR. As treatments such as interleukin-6 antagonists can normalise CRP levels, the erythrocyte sedimentation rate (ESR) of PMR-AS, the clinical (clin)-PMR-AS and the imputed-CRP (imp-CRP)-PMR-AS have been developed to avoid such bias. Our primary objective was to measure the correlation of these activity scores. Our secondary objective was to evaluate the concordance between different cutoffs of the PMR-ASs. Method Data from the Safety and Efficacy of tocilizumab versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence (SEMAPHORE) trial, a superiority randomised double-blind placebo-controlled trial, were subjected to post hoc analysis to compare the efficacy of tocilizumab versus placebo in patients with active PMR. The CRP-PMR-AS, ESR-PMR-AS, clin-PMR-AS and imp-CRP-PMR-AS were measured at every visit. The concordance and correlation between these scores were evaluated using kappa correlation coefficients, Bland-Altman correlations, intraclass correlation coefficients (ICCs) and scatter plots. Results A total of 101 patients were included in the SEMAPHORE trial, and 100 were analysed in this study. The correlation between the PMR-ASs was excellent, as the ICC and kappa were >0.85 from week 4 until week 24 (CRP-PMR-AS ≤10 or >10). Bland-Altman plots revealed that the differences between the CRP-PMR-AS and the other three scores were low. The cut-off values for the clin-PMR-AS were similar to those for the CRP-PMR-AS 86% of the time. Conclusion The correlation between all the PMR-ASs was excellent, reflecting the low weight of CRP. In clinical trials using drugs that have an impact on CRP, the derived activity scores can be used. Trial registration number NTC02908217.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.title.enConcordance and agreement between different activity scores in polymyalgia rheumatica
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/rmdopen-2023-003741en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed38490696en_US
bordeaux.journalRMD Openen_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04769967
hal.version1
hal.date.transferred2024-11-06T14:50:06Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BY-NCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=RMD%20Open&rft.date=2024&rft.volume=10&rft.issue=1&rft.au=D'AGOSTINO,%20Justine&SOUKI,%20Aghiles&LOHSE,%20Anne&CARVAJAL%20ALEGRIA,%20Guillermo&DERNIS,%20Emanuelle&rft.genre=article


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