Mostrar el registro sencillo del ítem

Correlated evolution of oxidative physiology and MHC-based immunosurveillance in birds

dc.rights.licenseopenen_US
dc.contributor.authorMINIAS, Piotr
hal.structure.identifierBabes-Bolyai University [Cluj-Napoca] [UBB]
dc.contributor.authorPAP, Peter L.
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorVINCZE, Orsolya
hal.structure.identifierBabes-Bolyai University [Cluj-Napoca] [UBB]
dc.contributor.authorVAGASI, Csongor I.
dc.date.accessioned2024-11-05T13:07:59Z
dc.date.available2024-11-05T13:07:59Z
dc.date.issued2024-06
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203127
dc.description.abstractEnMaintenance and activation of the immune system incur costs, not only in terms of substrates and energy but also via collateral oxidative damage to host cells or tissues during immune response. So far, associations between immune function and oxidative damage have been primarily investigated at intra-specific scales. Here, we hypothesized that pathogen-driven selection should favour the evolution of effective immunosurveillance mechanisms (e.g. major histocompatibility complex, MHC) and antioxidant defences to mitigate oxidative damage resulting from immune function. Using phylogenetically informed comparative approaches, we provided evidence for the correlated evolution of host oxidative physiology and MHC-based immunosurveillance in birds. Species selected for more robust MHC-based immunosurveillance (higher gene copy numbers and allele diversity) showed stronger antioxidant defences, although selection for MHC diversity still showed a positive evolutionary association with oxidative damage to lipids. Our results indicate that historical pathogen-driven selection for highly duplicated and diverse MHC could have promoted the evolution of efficient antioxidant mechanisms, but these evolutionary solutions may be insufficient to keep oxidative stress at bounds. Although the precise nature of mechanistic links between the MHC and oxidative stress remains unclear, our study suggests that a general evolutionary investment in immune function may require co-adaptations at the level of host oxidative metabolism.
dc.language.isoENen_US
dc.subject.enAntioxidant defence
dc.subject.enBirds
dc.subject.enEvolution
dc.subject.enImmunopathology
dc.subject.enMajor histocompatibility complex
dc.subject.enOxidative physiology
dc.title.enCorrelated evolution of oxidative physiology and MHC-based immunosurveillance in birds
dc.typeArticle de revueen_US
dc.identifier.doi10.1098/rspb.2024.0686en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed38889785en_US
bordeaux.journalProceedings of the Royal Society Ben_US
bordeaux.volume291en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue2025en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04767412
hal.version1
hal.date.transferred2024-11-05T13:08:03Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings%20of%20the%20Royal%20Society%20B&rft.date=2024-06&rft.volume=291&rft.issue=2025&rft.au=MINIAS,%20Piotr&PAP,%20Peter%20L.&VINCZE,%20Orsolya&VAGASI,%20Csongor%20I.&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem