Physical exercise restores adult neurogenesis deficits induced by simulated microgravity
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | GROS, Alexandra | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | FURLAN, Fandilla Marie | |
| hal.structure.identifier | Interdisciplinary Institute for Neuroscience [Bordeaux] [IINS] | |
| dc.contributor.author | ROUGLAN, Vanessa | |
| hal.structure.identifier | Interdisciplinary Institute for Neuroscience [Bordeaux] [IINS] | |
| dc.contributor.author | FAVEREAUX, Alexandre | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | BONTEMPI, Bruno
IDREF: 119124459 | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | MOREL, Jean-Luc | |
| dc.date.accessioned | 2024-11-04T10:03:01Z | |
| dc.date.available | 2024-11-04T10:03:01Z | |
| dc.date.issued | 2024-06-21 | |
| dc.identifier.issn | 2373-8065 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/203109 | |
| dc.description.abstractEn | Cognitive impairments have been reported in astronauts during spaceflights and documented in ground-based models of simulated microgravity (SMG) in animals. However, the neuronal causes of these behavioral effects remain largely unknown. We explored whether adult neurogenesis, known to be a crucial plasticity mechanism supporting memory processes, is altered by SMG. Adult male Long-Evans rats were submitted to the hindlimb unloading model of SMG. We studied the proliferation, survival and maturation of newborn cells in the following neurogenic niches: the subventricular zone (SVZ)/olfactory bulb (OB) and the dentate gyrus (DG) of the hippocampus, at different delays following various periods of SMG. SMG exposure for 7 days, but not shorter periods of 6 or 24 h, resulted in a decrease of newborn cell proliferation restricted to the DG. SMG also induced a decrease in short-term (7 days), but not long-term (21 days), survival of newborn cells in the SVZ/OB and DG. Physical exercise, used as a countermeasure, was able to reverse the decrease in newborn cell survival observed in the SVZ and DG. In addition, depending on the duration of SMG periods, transcriptomic analysis revealed modifications in gene expression involved in neurogenesis. These findings highlight the sensitivity of adult neurogenesis to gravitational environmental factors during a transient period, suggesting that there is a period of adaptation of physiological systems to this new environment. | |
| dc.description.sponsorship | Développment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004 | en_US |
| dc.description.sponsorship | Dynamiques des interactions hippocampo-corticales au cours de la formation des souvenirs récents et anciens: bases comportementales, cellulaires, moléculaires et fonctionnelles - ANR-14-CE13-0017 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title.en | Physical exercise restores adult neurogenesis deficits induced by simulated microgravity | |
| dc.title.alternative | NPJ Microgravity | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41526-024-00411-6 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 38906877 | en_US |
| bordeaux.journal | NPJ Microgravity | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Centre National d’Etudes Spatiales | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04764733 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-11-04T10:03:06Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NPJ%20Microgravity&rft.date=2024-06-21&rft.volume=10&rft.issue=1&rft.eissn=2373-8065&rft.issn=2373-8065&rft.au=GROS,%20Alexandra&FURLAN,%20Fandilla%20Marie&ROUGLAN,%20Vanessa&FAVEREAUX,%20Alexandre&BONTEMPI,%20Bruno&rft.genre=article |
