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Comparison of subconjunctival TRIamcinolone acetonide injection and intravitreal dexamethasone (OZurdex) injection for uveitic and postoperative macular oedema: the TRIOZ study

dc.rights.licenseopenen_US
hal.structure.identifierCentre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
dc.contributor.authorCOURET, Chloé
hal.structure.identifierNantes Université [Nantes Univ]
dc.contributor.authorQUINTART, Pierre-Antoine
hal.structure.identifierCentre d'investigation clinique (CIC) de Nantes -CIC Plurithématique [CIC 0004 - Nantes]
hal.structure.identifierCentre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
dc.contributor.authorPOINAS, Alexandra
hal.structure.identifierCentre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
dc.contributor.authorVIBET, Marie-Anne
hal.structure.identifierCentre Hospitalier Régional Universitaire de Tours [CHRU Tours]
dc.contributor.authorLE LEZ, Marie-Laure
hal.structure.identifierLille Inflammation Research International Center - U 995 [LIRIC]
dc.contributor.authorLABALETTE, Pierre
hal.structure.identifierImmunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] [I3]
dc.contributor.authorBODAGHI, Bahram
hal.structure.identifierHôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
hal.structure.identifierCentre de référence des Maladies Rares en Ophtalmologie [CHU HEGP] [OPHTARA]
hal.structure.identifierImmunologie des maladies virales, auto-immunes, hématologiques et bactériennes [IMVA-HB]
hal.structure.identifierInfectious Diseases Models for Innovative Therapies [IDMIT]
dc.contributor.authorLABETOULLE, Marc
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUGIER, Marie-Benedicte
hal.structure.identifierService d'ophtalmologie [CHRU Nancy]
dc.contributor.authorANGIOI, Karine
hal.structure.identifierHypoxie et PhysioPathologie [HP2]
dc.contributor.authorCHIQUET, Christophe
hal.structure.identifierFondation Ophtalmologique Adolphe de Rotschild
dc.contributor.authorTITAH, Cherif
hal.structure.identifierHôpital de la Croix-Rousse [CHU - HCL]
hal.structure.identifierMatériaux, ingénierie et science [Villeurbanne] [MATEIS]
dc.contributor.authorKODJIKIAN, Laurent
hal.structure.identifierHôpital Pasteur [Nice] [CHU]
dc.contributor.authorBAILLIF, Stephanie
hal.structure.identifierCentre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
hal.structure.identifierService d'Ophtalmologie (CHU de Dijon)
dc.contributor.authorCREUZOT-GARCHER, Catherine
hal.structure.identifierCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts [CHNO]
hal.structure.identifierUniversity of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] [UPMC]
hal.structure.identifierSorbonne Université [SU]
dc.contributor.authorERRERA, Marie-Hélène
hal.structure.identifierHôtel-Dieu de Nantes
dc.contributor.authorWEBER, Michel
dc.date.accessioned2024-10-31T08:15:23Z
dc.date.available2024-10-31T08:15:23Z
dc.date.issued2024-08-21
dc.identifier.issn0007-1161en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203064
dc.description.abstractEnAims To compare effectiveness of subconjunctival triamcinolone acetonide injections and intravitreal injections of dexamethasone 700 µg implants in reducing central macular thickness (CMT) in uveitic and postoperative macular oedema (ME). Methods We conducted an open-label, French multicentre randomised comparative trial with a logarithmic CMT non-inferiority margin set at 0.06. Patients were adults with non-infectious inflammatory ME, without any contraindication to the treatments. They were randomised 1:1 to receive either triamcinolone or dexamethasone. The primary endpoint was the difference in CMT among treated eyes between baseline and 2 months, measured with spectral-domain optical coherence tomography. Secondary outcomes included visual acuity, laser flare, vitreous haze, duration of action, tolerance to injections and adverse events. Results Between January 2016 and January 2020, 106 patients were enrolled (54 in the triamcinolone group and 52 in the dexamethasone group). Subconjunctival triamcinolone injections seemed to be non-inferior to intravitreal dexamethasone injections, especially at month 3 (and nearly at month 1). Nevertheless, we could not demonstrate it, with a treatment effect at month 2 of 0.05 (0.01 ; 0.09) (p value=0.001). This was corroborated by post hoc analyses in the postoperative subgroup, for whom the non-inferiority was nearly demonstrated at month 2 with a treatment effect of 0.02 (−0.03 ; 0.08) (p=0.37). There was no significant difference in the occurrence of adverse effects. Conclusion We could not demonstrate the non-inferiority of triamcinolone injections at month 2. Nevertheless, they showed some efficacity, particularly in treating postoperative ME, being as safe as dexamethasone injections, without any loss of chance if a therapeutic switch is necessary.
dc.language.isoENen_US
dc.subject.enClinical Trial
dc.subject.enDrugs
dc.subject.enInflammation
dc.subject.enRetina
dc.title.enComparison of subconjunctival TRIamcinolone acetonide injection and intravitreal dexamethasone (OZurdex) injection for uveitic and postoperative macular oedema: the TRIOZ study
dc.title.alternativeBr J Ophthalmolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/bjo-2023-325128en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Organes des sensen_US
dc.identifier.pubmed39168590en_US
bordeaux.journalBritish Journal of Ophthalmologyen_US
bordeaux.pagebjo-2023-325128en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04736939
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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