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Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults
dc.rights.license | open | en_US |
hal.structure.identifier | Washington University School of Medicine [Saint Louis, MO] | |
dc.contributor.author | AGGARWAL, Geetika | |
hal.structure.identifier | Washington University School of Medicine [Saint Louis, MO] | |
dc.contributor.author | MORLEY, John | |
dc.contributor.author | VELLAS, Bruno | |
hal.structure.identifier | Washington University School of Medicine [Saint Louis, MO] | |
dc.contributor.author | NGUYEN, Andrew | |
hal.structure.identifier | International Centre for Radio Astronomy Research [ICRAR] | |
dc.contributor.author | BUTLER, Andrew | |
dc.contributor.author | GUYONNET, Sophie | |
hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
dc.contributor.author | CARRIÉ, Isabelle | |
hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
dc.contributor.author | BRIGITTE, Lauréane | |
hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
dc.contributor.author | FAISANT, Catherine | |
hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
dc.contributor.author | LALA, Françoise | |
hal.structure.identifier | Université Toulouse III - Paul Sabatier [UT3] | |
dc.contributor.author | DELRIEU, Julien | |
hal.structure.identifier | Pôle Gériatrie [CHU Toulouse] | |
hal.structure.identifier | Equipe Vieillissement (CERPOP) | |
dc.contributor.author | VILLARS, Hélène | |
dc.contributor.author | COMBROUZE, Emeline | |
dc.contributor.author | BADUFLE, Carole | |
dc.contributor.author | ZUERAS, Audrey | |
hal.structure.identifier | Centre de recherche en épidémiologie et santé des populations [CESP] | |
hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
hal.structure.identifier | Equipe Vieillissement (CERPOP) | |
dc.contributor.author | ANDRIEU, Sandrine | |
hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
dc.contributor.author | CANTET, Christelle | |
hal.structure.identifier | Laboratoire Eau Environnement et Systèmes Urbains [LEESU] | |
hal.structure.identifier | IUT - Sénart Fontainebleau, 36 Rue Georges Charpak, 77567 Lieusaint | |
dc.contributor.author | MORIN, Christophe | |
dc.contributor.author | VAN KAN, Gabor | |
hal.structure.identifier | Université Paris Descartes - École de sages-femmes Baudelocque [UPD ESF Baudelocque] | |
dc.contributor.author | DUPUY, Charlotte | |
dc.contributor.author | ROLLAND, Yves | |
hal.structure.identifier | Institut de Recherche sur les CERamiques [IRCER] | |
dc.contributor.author | CAILLAUD, Céline | |
dc.contributor.author | OUSSET, Pierre-Jean | |
hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
dc.contributor.author | LALA, Françoise | |
hal.structure.identifier | University of Washington [Seattle] | |
dc.contributor.author | WILLIS, Sherry | |
hal.structure.identifier | Centre de recherche de l'Institut universitaire de gériatrie de Montreal [CRIUGM] | |
dc.contributor.author | BELLEVILLE, Sylvie | |
hal.structure.identifier | Centre de recherche de l'Institut universitaire de gériatrie de Montreal [CRIUGM] | |
dc.contributor.author | GILBERT, Brigitte | |
dc.contributor.author | FONTAINE, Francine | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DARTIGUES, Jean-Francois | |
dc.contributor.author | MARCET, Isabelle | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DELVA, Fleur | |
dc.contributor.author | FOUBERT, Alexandra | |
dc.contributor.author | CERDA, Sandrine | |
dc.contributor.author | COSTES, Corinne | |
hal.structure.identifier | École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS] | |
hal.structure.identifier | Laboratoire de génie des procédés - environnement - agroalimentaire [GEPEA] | |
hal.structure.identifier | Optimisation - Système - Energie [GEPEA-OSE] | |
dc.contributor.author | ROUAUD, Olivier | |
hal.structure.identifier | Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon] | |
dc.contributor.author | MANCKOUNDIA, Patrick | |
hal.structure.identifier | CHU Dijon | |
dc.contributor.author | QUIPOURT, Valérie | |
hal.structure.identifier | Service de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD) | |
dc.contributor.author | MARILIER, Sophie | |
hal.structure.identifier | Cabinet médical [Dijon] | |
dc.contributor.author | FRANON, Evelyne | |
dc.contributor.author | BORIES, Lawrence | |
dc.contributor.author | PADER, Marie-Laure | |
dc.contributor.author | BASSET, Marie-France | |
dc.contributor.author | LAPOUJADE, Bruno | |
dc.contributor.author | FAURE, Valérie | |
dc.contributor.author | TONG, Michael | |
dc.contributor.author | MALICK-LOISEAU, Christine | |
dc.contributor.author | CAZABAN-CAMPISTRON, Evelyne | |
dc.contributor.author | DESCLAUX, Françoise | |
dc.contributor.author | BLATGE, Colette | |
dc.contributor.author | DANTOINE, Thierry | |
dc.contributor.author | LAUBARIE-MOURET, Cécile | |
dc.contributor.author | SAULNIER, Isabelle | |
dc.contributor.author | CLÉMENT, Jean-Pierre | |
dc.contributor.author | PICAT, Marie-Agnès | |
dc.contributor.author | BERNARD-BOURZEIX, Laurence | |
dc.contributor.author | WILLEBOIS, Stéphanie | |
dc.contributor.author | DÉSORMAIS, Iléana | |
dc.contributor.author | CARDINAUD, Noëlle | |
dc.contributor.author | BONNEFOY, Marc | |
dc.contributor.author | LIVET, Pierre | |
dc.contributor.author | REBAUDET, Pascale | |
dc.contributor.author | GÉDÉON, Claire | |
dc.contributor.author | BURDET, Catherine | |
dc.contributor.author | TERRACOL, Flavien | |
dc.contributor.author | PESCE, Alain | |
dc.contributor.author | ROTH, Stéphanie | |
dc.contributor.author | CHAILLOU, Sylvie | |
dc.contributor.author | LOUCHART, Sandrine | |
dc.contributor.author | SUDRES, Kristel | |
dc.contributor.author | LEBRUN, Nicolas | |
dc.contributor.author | BARRO-BELAYGUES, Nadège | |
dc.contributor.author | TOUCHON, Jacques | |
dc.contributor.author | BENNYS, Karim | |
dc.contributor.author | GABELLE, Audrey | |
dc.contributor.author | ROMANO, Aurélia | |
dc.contributor.author | TOUATI, Lynda | |
dc.contributor.author | MARELLI, Cécilia | |
dc.contributor.author | PAYS, Cécile | |
dc.contributor.author | ROBERT, Philippe | |
dc.contributor.author | LE DUFF, Franck | |
dc.contributor.author | GERVAIS, Claire | |
dc.contributor.author | GONFRIER, Sébastien | |
dc.contributor.author | GASNIER, Yannick | |
dc.contributor.author | BORDES, Serge | |
dc.contributor.author | BEGORRE, Danièle | |
dc.contributor.author | CARPUAT, Christian | |
dc.contributor.author | KHALES, Khaled | |
dc.contributor.author | LEFEBVRE, Jean-François | |
dc.contributor.author | EL IDRISSI, Samira | |
dc.contributor.author | SKOLIL, Pierre | |
dc.contributor.author | SALLES, Jean-Pierre | |
dc.contributor.author | DUFOUIL, Carole | |
dc.contributor.author | LEHÉRICY, Stéphane | |
dc.contributor.author | CHUPIN, Marie | |
dc.contributor.author | MANGIN, Jean-François | |
dc.contributor.author | BOUHAYIA, Ali | |
dc.contributor.author | ALLARD, Michèle | |
dc.contributor.author | RICOLFI, Frédéric | |
dc.contributor.author | DUBOIS, Dominique | |
dc.contributor.author | MARTEL, Marie | |
dc.contributor.author | COTTON, François | |
dc.contributor.author | BONAFÉ, Alain | |
dc.contributor.author | CHANALET, Stéphane | |
dc.contributor.author | HUGON, Françoise | |
dc.contributor.author | BONNEVILLE, Fabrice | |
dc.contributor.author | COGNARD, Christophe | |
dc.contributor.author | CHOLLET, François | |
dc.contributor.author | PAYOUX, Pierre | |
dc.contributor.author | VOISIN, Thierry | |
hal.structure.identifier | Université Toulouse III - Paul Sabatier [UT3] | |
hal.structure.identifier | Centre d'Epidémiologie et de Recherche en santé des POPulations [CERPOP] | |
hal.structure.identifier | Equipe Vieillissement (CERPOP) | |
dc.contributor.author | DELRIEU, Julien | |
dc.contributor.author | PEIFFER, Sophie | |
dc.contributor.author | HITZEL, Anne | |
dc.contributor.author | ALLARD, Michèle | |
dc.contributor.author | ZANCA, Michel | |
dc.contributor.author | MONTEIL, Jacques | |
dc.contributor.author | DARCOURT, Jacques | |
dc.contributor.author | MOLINIER, Laurent | |
dc.contributor.author | DERUMEAUX, Hélène | |
dc.contributor.author | COSTA, Nadège | |
dc.contributor.author | PERRET, Bertrand | |
dc.contributor.author | VINEL, Claire | |
dc.contributor.author | CASPAR-BAUGUIL, Sylvie | |
dc.contributor.author | OLIVIER-ABBAL, Pascale | |
hal.structure.identifier | Centre de recherche en épidémiologie et santé des populations [CESP] | |
hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
hal.structure.identifier | Equipe Vieillissement (CERPOP) | |
dc.contributor.author | ANDRIEU, Sandrine | |
hal.structure.identifier | Centre Hospitalier Universitaire de Toulouse [CHU Toulouse] | |
hal.structure.identifier | Centre d'Epidémiologie et de Recherche en santé des POPulations [CERPOP] | |
hal.structure.identifier | Equipe Vieillissement (CERPOP) | |
dc.contributor.author | CANTET, Christelle | |
dc.contributor.author | COLEY, Nicola | |
dc.date.accessioned | 2024-10-30T14:23:42Z | |
dc.date.available | 2024-10-30T14:23:42Z | |
dc.date.issued | 2023-05-26 | |
dc.identifier.issn | 2509-2715 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/202998 | |
dc.description.abstractEn | Abstract The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA and proteomic risk indicators for dementia. Here we report that plasma adropin concentrations predict risk for cognitive decline in the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n = 452). Cognitive ability was evaluated using a composite cognitive score (CCS) that assessed four domains: memory, language, executive function, and orientation. Relationships between plasma adropin concentrations and changes in CCS (∆CCS) were examined using Cox Proportional Hazards Regression, or by grouping into tertiles ranked low to high by adropin values and controlling for age, time between baseline and final visits, baseline CCS, and other risk factors (e.g., education, medication, APOE4 status). Risk of cognitive decline (defined as a ∆CCS of − 0.3 or more) decreased with increasing plasma adropin concentrations (hazard ratio = 0.873, 95% CI 0.780–0.977, P = 0.018). Between adropin tertiles, ∆CCS was significantly different ( P = 0.01; estimated marginal mean ± SE for the 1st to 3rd tertile, − 0.317 ± 0.064; − 0.275 ± 0.063; − 0.042 ± 0.071; n = 133,146, and 130, respectively; P < 0.05 for 1st vs. 2nd and 3rd adropin tertiles). Normalized plasma Aß 42/40 ratio and plasma neurofilament light chain, indicators of neurodegeneration, were significantly different between adropin tertile. These differences were consistent with reduced risk of cognitive decline with higher plasma adropin levels. Overall, these results suggest cognitive decline is reduced in community-dwelling older adults with higher circulating adropin levels. Further studies are needed to determine the underlying causes of the relationship and whether increasing adropin levels can delay cognitive decline. | |
dc.language.iso | EN | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/ | |
dc.subject.en | Adropin | |
dc.subject.en | Cognitive decline | |
dc.subject.en | Dementia | |
dc.subject.en | Plasma biomarkers | |
dc.subject.en | Aging | |
dc.title.en | Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1007/s11357-023-00824-3 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 37233882 | en_US |
bordeaux.journal | GeroScience | en_US |
bordeaux.page | 897-911 | en_US |
bordeaux.volume | 46 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 1 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | EPICENE_BPH | en_US |
bordeaux.team | ACTIVE_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | hal | |
hal.identifier | hal-04492066 | |
hal.version | 1 | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | false | |
workflow.import.source | hal | |
dc.rights.cc | Pas de Licence CC | en_US |
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