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Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial

dc.rights.licenseopenen_US
hal.structure.identifierGérontopôle
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorDELRIEU, Julien
hal.structure.identifierEquipe Vieillissement (CERPOP)
hal.structure.identifierGérontopôle
dc.contributor.authorVELLAS, Bruno
hal.structure.identifierEquipe Vieillissement (CERPOP)
hal.structure.identifierGérontopôle
dc.contributor.authorGUYONNET, Sophie
hal.structure.identifierCentre d'Epidémiologie et de Recherche en santé des POPulations [CERPOP]
hal.structure.identifierGérontopôle
dc.contributor.authorCANTET, Christelle
dc.contributor.authorOVOD, Vitaliy
hal.structure.identifierApplied Mechanics and Structure Safety Key Laboratory of Sichuan Province
dc.contributor.authorLI, Yan
hal.structure.identifierDepartments of Chemistry and Biochemistry
dc.contributor.authorBOLLINGER, James
hal.structure.identifierWashington University School of Medicine [Saint Louis, MO]
dc.contributor.authorBATEMAN, Randall
hal.structure.identifierEquipe Vieillissement (CERPOP)
hal.structure.identifierGérontopôle
dc.contributor.authorANDRIEU, Sandrine
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorCARRIÉ, Isabelle
dc.contributor.authorBRIGITTE, Lauréane
dc.contributor.authorFAISANT, Catherine
dc.contributor.authorLALA, Françoise
hal.structure.identifierPôle Gériatrie [CHU Toulouse]
hal.structure.identifierEquipe Vieillissement (CERPOP)
dc.contributor.authorVILLARS, Hélène
dc.contributor.authorCOMBROUZE, Emeline
dc.contributor.authorBADUFLE, Carole
dc.contributor.authorZUERAS, Audrey
hal.structure.identifierLaboratoire Eau Environnement et Systèmes Urbains [LEESU]
hal.structure.identifierIUT - Sénart Fontainebleau, 36 Rue Georges Charpak, 77567 Lieusaint
dc.contributor.authorMORIN, Christophe
dc.contributor.authorVAN KAN, Gabor Abellan
hal.structure.identifierUniversité Paris Descartes - École de sages-femmes Baudelocque [UPD ESF Baudelocque]
dc.contributor.authorDUPUY, Charlotte
dc.contributor.authorROLLAND, Yves
hal.structure.identifierInstitut de Recherche sur les CERamiques [IRCER]
dc.contributor.authorCAILLAUD, Céline
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorOUSSET, Pierre-Jean
dc.contributor.authorWILLIS, Sherry
hal.structure.identifierCentre de recherche de l'Institut universitaire de gériatrie de Montreal [CRIUGM]
dc.contributor.authorBELLEVILLE, Sylvie
hal.structure.identifierCentre de recherche de l'Institut universitaire de gériatrie de Montreal [CRIUGM]
dc.contributor.authorGILBERT, Brigitte
dc.contributor.authorFONTAINE, Francine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
dc.contributor.authorMARCET, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELVA, Fleur
dc.contributor.authorFOUBERT, Alexandra
dc.contributor.authorCERDA, Sandrine
dc.contributor.authorCOSTES, Corinne
dc.contributor.authorROUAUD, Olivier
dc.contributor.authorMANCKOUNDIA, Patrick
dc.contributor.authorQUIPOURT, Valérie
dc.contributor.authorMARILIER, Sophie
dc.contributor.authorFRANON, Evelyne
dc.contributor.authorBORIES, Lawrence
dc.contributor.authorPADER, Marie-Laure
dc.contributor.authorBASSET, Marie-France
dc.contributor.authorLAPOUJADE, Bruno
dc.contributor.authorFAURE, Valérie
dc.contributor.authorTONG, Michael Li Yung
dc.contributor.authorMALICK-LOISEAU, Christine
dc.contributor.authorCAZABAN-CAMPISTRON, Evelyne
dc.contributor.authorDESCLAUX, Françoise
dc.contributor.authorBLATGE, Colette
dc.contributor.authorDANTOINE, Thierry
dc.contributor.authorLAUBARIE-MOURET, Cécile
dc.contributor.authorSAULNIER, Isabelle
dc.contributor.authorCLÉMENT, Jean-Pierre
dc.contributor.authorPICAT, Marie-Agnès
dc.contributor.authorBERNARD-BOURZEIX, Laurence
dc.contributor.authorWILLEBOIS, Stéphanie
dc.contributor.authorDÉSORMAIS, Iléana
dc.contributor.authorCARDINAUD, Noëlle
dc.contributor.authorBONNEFOY, Marc
dc.contributor.authorLIVET, Pierre
dc.contributor.authorREBAUDET, Pascale
dc.contributor.authorGÉDÉON, Claire
dc.contributor.authorBURDET, Catherine
dc.contributor.authorTERRACOL, Flavien
dc.contributor.authorPESCE, Alain
dc.contributor.authorROTH, Stéphanie
dc.contributor.authorCHAILLOU, Sylvie
dc.contributor.authorLOUCHART, Sandrine
dc.contributor.authorSUDRES, Kristel
dc.contributor.authorLEBRUN, Nicolas
dc.contributor.authorBARRO-BELAYGUES, Nadège
dc.contributor.authorTOUCHON, Jacques
dc.contributor.authorBENNYS, Karim
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorROMANO, Aurélia
dc.contributor.authorTOUATI, Lynda
dc.contributor.authorMARELLI, Cécilia
dc.contributor.authorPAYS, Cécile
dc.contributor.authorROBERT, Philippe
dc.contributor.authorLE DUFF, Franck
dc.contributor.authorGERVAIS, Claire
dc.contributor.authorGONFRIER, Sébastien
dc.contributor.authorGASNIER, Yannick
dc.contributor.authorBORDES, Serge
dc.contributor.authorBEGORRE, Danièle
dc.contributor.authorCARPUAT, Christian
dc.contributor.authorKHALES, Khaled
dc.contributor.authorLEFEBVRE, Jean-François
dc.contributor.authorEL IDRISSI, Samira Misbah
dc.contributor.authorSKOLIL, Pierre
dc.contributor.authorSALLES, Jean-Pierre
dc.contributor.authorCOLEY, Nicola
dc.date.accessioned2024-10-30T13:05:32Z
dc.date.available2024-10-30T13:05:32Z
dc.date.issued2023-10-23
dc.identifier.issn1758-9193en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202994
dc.description.abstractEnAbstract Background In MAPT (Multidomain Alzheimer Preventive Trial), a cognitive effect of multidomain intervention (MI) was showed in non-demented subjects with positive amyloid PET. However, screening eligible patients for multidomain intervention by PET is difficult to generalize in real-world settings. Methods MAPT study was a 3-year, randomized, placebo-controlled trial followed by a 2-year observational and optional extension. All participants were non-demented and randomly assigned (1:1:1:1) to the MI plus omega 3, MI plus placebo, omega 3 alone, or placebo alone group. The objectives were to assess the cognitive effect of MAPT interventions (omega 3 supplementation, MI, combined intervention) in non-demented subjects according to amyloid blood status at 12, 36, and 60 months. In this subgroup analysis (n = 483), amyloid status was defined by plasma Aβ42/40 ratio (cutoff ≤ 0.0107). The primary outcome measure was the change in cognitive composite score after a 1, 3, and 5-year clinical follow-up. Results The intention-to-treat (ITT) population included 483 subjects (161 positive and 322 negative amyloid participants based on plasma Aβ42/40 ratio). In the positive amyloid ITT population, we showed a positive effect of MI plus omega 3 on the change in composite cognitive score in 12 (raw p = .0350, 0.01917, 95% CI = [0.0136 to 0.3699]) and 36 months (raw p = .0357, 0.2818, 95% CI = [0.0190 to 0.5446]). After correction of multiple comparisons and adjustments, these differences were not significant (adjusted p = .1144 and .0690). In the per-protocol positive amyloid group (n = 154), we observed a significant difference between the combined intervention and placebo groups at 12 (p = .0313, 0.2424, 0.0571 to 0.4276) and 36 months (p = .0195, 0.3747, 0.1055 to 0.6439) persisting after adjustment. In the ITT and per-protocol analyses, no cognitive effect was observed in the positive and negative amyloid group at 60-month visit. Conclusions These findings suggest a benefit of MI plus omega 3 in positive blood amyloid subjects. This promising trend needs to be confirmed before using blood biomarkers for screening in preventive trials. Trial registration ClinicalTrials.gov Identifier: NCT01513252.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enCognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial
dc.title.alternativeAlzheimers Res Theren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s13195-023-01325-3en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37872582en_US
bordeaux.journalAlzheimer's Research and Therapyen_US
bordeaux.page105837en_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04352693
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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