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Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19

dc.rights.licenseopenen_US
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorHOCINI, Hakim
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorWIEDEMANN, Aurélie
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorBLENGIO, Fabiola
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorLEFEBVRE, Cécile
hal.structure.identifierCentre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique [CIC 1425]
hal.structure.identifierInfection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
dc.contributor.authorCERVANTES-GONZALEZ, Minerva
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorFOUCAT, Emile
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorTISSERAND, Pascaline
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorSURENAUD, Mathieu
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorCOLÉON, Séverin
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPRAGUE, Melanie
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorGUILLAUMAT, Lydia
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
dc.contributor.authorKRIEF, Corinne
hal.structure.identifierCentre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] [CHUV]
dc.contributor.authorFENWICK, Craig
hal.structure.identifierCentre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique [CIC 1425]
hal.structure.identifierInfection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
dc.contributor.authorLAOUÉNAN, Cédric
hal.structure.identifierInfection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
dc.contributor.authorBOUADMA, Lila
hal.structure.identifierInfection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
hal.structure.identifierServices de Maladies Infectieuses et Tropicales [CHU Bichat]
dc.contributor.authorGHOSN, Jade
hal.structure.identifierIMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" [Créteil] [U955 Inserm - UPEC]
hal.structure.identifierCentre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] [CHUV]
dc.contributor.authorPANTALEO, Giuseppe
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorABEL, Laurent
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorABROUS, Amal
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorANDREJAK, Claire
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorANGOULVANT, François
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorBACHELET, Delphine
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorBARTOLI, Marie
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorBEHILILL, Sylvie
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorBELUZE, Marine
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorBHAVSAR, Krishna
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorCHAIR, Anissa
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorCHARPENTIER, Charlotte
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorCHENARD, Léo
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorCHIROUZE, Catherine
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorCOUFFIN-CADIERGUES, Sandrine
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorCOUFFIGNAL, Camille
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorCASTRO, Nathalie
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorDEBRAY, Marie-Pierre
hal.structure.identifierFrench COVID cohort study group
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
dc.contributor.authorDEPLANQUE, Dominique
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorDESCAMPS, Diane
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorDIALLO, Alpha
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorSILVA, Fernanda
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorDORIVAL, Céline
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorDUVAL, Xavier
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorELOY, Philippine
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorENOUF, Vincent
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorESPEROU, Hélène
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorESPOSITO-FARESE, Marina
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorETIENNE, Manuel
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorFLORENCE, Aline-Marie
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorGAYMARD, Alexandre
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorGIGANTE, Tristan
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorGILG, Morgane
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorGOEHRINGER, François
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorGUEDJ, Jérémie
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorHOUAS, Ikram
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorHOFFMANN, Isabelle
hal.structure.identifierFrench COVID cohort study group
hal.structure.identifierCIC - HEGP [CIC 1418]
dc.contributor.authorHULOT, Jean-Sébastien
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorJAAFOURA, Salma
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorJAMARD, Simon
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorKAFIF, Ouifiya
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorKHALIL, Antoine
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorLAFHEJ, Nadhem
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorLARIBI, Samira
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorLE, Minh
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorHINGRAT, Quentin
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorMESTRE, Soizic
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorLETROU, Sophie
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorLINA, Bruno
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorLINGAS, Guillaume
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorMALVY, Denis
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorMENTRÉ, France
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorMOUQUET, Hugo
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorNEANT, Nadège
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorPAUL, Christelle
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorPAPADOPOULOS, Aurélie
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorPETROV-SANCHEZ, Ventzislava
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorPEYTAVIN, Gilles
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorPIQUARD, Valentine
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorPICONE, Olivier
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorROSA-CALATRAVA, Manuel
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorROSSIGNOL, Bénédicte
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorROSSIGNOL, Patrick
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorROY, Carine
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorSCHNEIDER, Marion
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorTARDIVON, Coralie
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorTIMSIT, Jean-François
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorTUBIANA, Sarah
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorWERF, Sylvie
hal.structure.identifierFrench COVID cohort study group
dc.contributor.authorVISSEAUX, Benoit
hal.structure.identifierGroupe Henri Mondor-Albert Chenevier
dc.contributor.authorLÉVY, Yves
dc.date.accessioned2024-10-30T11:08:12Z
dc.date.available2024-10-30T11:08:12Z
dc.date.issued2023-03-21
dc.identifier.issn0271-9142en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202991
dc.description.abstractEnPurpose Following a severe COVID-19 infection, a proportion of individuals develop prolonged symptoms. We investigated the immunological dysfunction that underlies the persistence of symptoms months after the resolution of acute COVID-19. Methods We analyzed cytokines, cell phenotypes, SARS-CoV-2 spike-specific and neutralizing antibodies, and whole blood gene expression profiles in convalescent severe COVID-19 patients 1, 3, and 6 months following hospital discharge. Results We observed persistent abnormalities until month 6 marked by (i) high serum levels of monocyte/macrophage and endothelial activation markers, chemotaxis, and hematopoietic cytokines; (ii) a high frequency of central memory CD4 + and effector CD8 + T cells; (iii) a decrease in anti-SARS-CoV-2 spike and neutralizing antibodies; and (iv) an upregulation of genes related to platelet, neutrophil activation, erythrocytes, myeloid cell differentiation, and RUNX1 signaling. We identified a “core gene signature” associated with a history of thrombotic events, with upregulation of a set of genes involved in neutrophil activation, platelet, hematopoiesis, and blood coagulation. Conclusion The lack of restoration of gene expression to a normal profile after up to 6 months of follow-up, even in asymptomatic patients who experienced severe COVID-19, signals the need to carefully extend their clinical follow-up and propose preventive measures.
dc.description.sponsorshipInitiative for the creation of a Vaccine Research Instituteen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCOVID-19 disease
dc.subject.enpost-acute COVID-19 syndrome
dc.subject.enthrombosis
dc.title.enNeutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19
dc.title.alternativeJ Clin Immunolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s10875-023-01459-xen_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed36943669en_US
dc.description.sponsorshipEuropeCorona Accelerated R&D in Europeen_US
bordeaux.journalJournal of Clinical Immunologyen_US
bordeaux.page882-893en_US
bordeaux.volume43en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04373844
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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