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Self-assembly of well-defined triblock copolymers based on poly(lactic acid) and poly(oligo(ethylene glycol) methyl ether methacrylate) prepared by ATRP

dc.rights.licenseopen
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorCOUMES, Fanny
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorBEAUTÉ, Louis
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorDOMURADO, Dominique
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorLI, Suming
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorCOUDANE, Jean
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorDARCOS, Vincent
dc.date.accessioned2020
dc.date.available2020
dc.date.created2016
dc.date.issued2016
dc.identifier.issn2046-2069
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20275
dc.description.abstractEnSelf-assembly of a series of amphiphilic poly(oligo(ethylene glycol) methyl ether methacrylate)-block-poly(lactic acid)-block-poly(oligo(ethylene glycol) methyl ether methacrylate) (P(OEGMA)-b-PLLA-b-P(OEGMA)) copolymers was investigated. The copolymers were synthesized by a combination of ring-opening polymerization (ROP) of L-lactide and atom transfer radical polymerization (ATRP) of oligo ethylene glycol methyl ether methacrylate (OEGMA). The resulting brush-like triblock copolymers were characterized by H-1 NMR and size exclusion chromatography. Self-assembly behavior of the copolymers in deionized water was investigated by fluorescence spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The critical aggregation concentration ranged from 50 to 160 mg L-1 depending on the composition. The diameter of the nanoparticles (NPs) was determined by DLS and TEM. Images showed that these nano-sized objects displayed spherical and worm-like morphology with a length increasing with the hydrophilic content. Preliminary studies of drug loading and drug release with a water-insoluble model drug, namely curcumin, showed that these NPs are potential candidates for drug delivery carriers.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.subject.enMICELLES
dc.subject.enAMBIENT-TEMPERATURE
dc.subject.enPEG NANOPARTICLES
dc.subject.enAQUEOUS-MEDIA
dc.subject.enTRANSFER RADICAL POLYMERIZATION
dc.subject.enTARGETED DRUG-DELIVERY
dc.subject.enCORE-SHELL STRUCTURE
dc.subject.enBLOCK-COPOLYMER
dc.subject.enPOLY(ETHYLENE GLYCOL)
dc.subject.enDOXORUBICIN DELIVERY
dc.title.enSelf-assembly of well-defined triblock copolymers based on poly(lactic acid) and poly(oligo(ethylene glycol) methyl ether methacrylate) prepared by ATRP
dc.typeArticle de revue
dc.identifier.doi10.1039/c6ra07535e
dc.subject.halChimie/Polymères
bordeaux.journalRSC Advances
bordeaux.page53370-53377
bordeaux.volume6
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue58
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01360836
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01360836v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=RSC%20Advances&rft.date=2016&rft.volume=6&rft.issue=58&rft.spage=53370-53377&rft.epage=53370-53377&rft.eissn=2046-2069&rft.issn=2046-2069&rft.au=COUMES,%20Fanny&BEAUT%C3%89,%20Louis&DOMURADO,%20Dominique&LI,%20Suming&LECOMMANDOUX,%20Sebastien&rft.genre=article


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