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Low-dose methadone added to another opioid for cancer pain: a multicentre prospective study

dc.rights.licenseopenen_US
hal.structure.identifierUniversité Paris Cité [UPCité]
hal.structure.identifierHôpital Lariboisière-Fernand-Widal [APHP]
dc.contributor.authorTREILLET, Erwan
hal.structure.identifierCentre pour l'innovation en cancérologie de Lyon [CICLY]
dc.contributor.authorPERCEAU-CHAMBARD, Elise
hal.structure.identifierCentre pour l'innovation en cancérologie de Lyon [CICLY]
dc.contributor.authorECONOMOS, Guillaume
hal.structure.identifierCentre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
dc.contributor.authorCHEVALIER, Luc
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorPICARD, Stéphane
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFRASCA, Matthieu
dc.contributor.authorPOUGET, Julie
hal.structure.identifierInstitut des Neurosciences Cellulaires et Intégratives [INCI]
dc.contributor.authorCALVEL, Laurent
dc.contributor.authorTREMELLAT-FALIERE, Flora
dc.contributor.authorMAJERUS, Maxime
dc.contributor.authorQUESNEL, Paul Antoine
dc.contributor.authorCHIQUET, Romain
hal.structure.identifierCentre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
dc.contributor.authorEVIN, Adrien
dc.contributor.authorSEVEQUE, Marie-Anne
hal.structure.identifierService d'Oncologie médicale [CHU Henri Mondor]
hal.structure.identifierUniversité Paris-Est Créteil Val-de-Marne - Paris 12 [UPEC UP12]
dc.contributor.authorLEBEL, Audrey
dc.contributor.authorHARDOUIN, Ines
hal.structure.identifierInstitut Curie [Paris]
dc.contributor.authorBURNOD, Alexis
hal.structure.identifierCentre Léon Bérard [Lyon]
dc.contributor.authorRENARD, Olivier
dc.contributor.authorBESSODES, Pauline
dc.contributor.authorGIET, Olivier
hal.structure.identifierNeurophysiologie Respiratoire Expérimentale et Clinique [UMRS 1158]
dc.contributor.authorSERRESSE, Laure
dc.date.accessioned2024-10-24T07:34:54Z
dc.date.available2024-10-24T07:34:54Z
dc.date.issued2024-10-09
dc.identifier.issn0941-4355en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202695
dc.description.abstractEnContext: The use of methadone for cancer pain management is gaining wider acceptance. However, switching to methadone treatment can still pose challenges. Consequently, there is ongoing development of its use in low doses in combination with other opioids, despite a lack of clinical evidence regarding its efficacy and safety.Objectives: This study aimed to evaluate the efficacy and tolerability of low-dose methadone in combination with another opioid in patients with moderate-to-severe cancer-related pain in a clinical setting.Patients and methods: This was a prospective, open-label study conducted in 19 pain and/or palliative care centres treating patients with cancer-related pain. Pain intensity, patients' global impression of change, and adverse effects were assessed on day 7 and day 14. The main outcome measure was the proportion of responders.Results: The study included 92 patients. The daily dose of methadone was 3 [3-6] mg at baseline, 9 [4-10] mg on day 7 and 10 [6-15] mg on day 14. The NRS pain ratings significantly decreased from 7 [6-8] at baseline to 5 [3-6] on visit 2 (p < .0001) and 4 [3-6] on visit 3 (p < .0001). Similarly, the VRS pain ratings decreased from 3 [3-3] at baseline to 2 [2-3] on visit 2 (p = 0.026) and 2 [1-3] (p < 0.001) on visit 3. At Visits 1 and 2, half of the patients were considered Responders. Of those responders, 73.5% were High-Responders at Visit 1 and 58.7% were High-Responders at Visit 2. No adverse events related to the risk of QT prolongation, overdose, or drug interactions were reported.Conclusion For patients experiencing moderate to severe cancer-related pain despite initial opioid treatment, our study found that low-dose methadone, when used in combination with another opioid, was both safe and effective. This supports the use of methadone as an adjunct to opioid-based treatment for cancer pain.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enCancer pain
dc.subject.enMethadone co-analgesia
dc.subject.enTitration
dc.subject.enEfficacy
dc.subject.enTolerance
dc.title.enLow-dose methadone added to another opioid for cancer pain: a multicentre prospective study
dc.title.alternativeSupport Care Canceren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00520-024-08835-2en_US
dc.subject.halSciences du Vivant [q-bio]/Canceren_US
dc.subject.halSciences cognitives/Neurosciencesen_US
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologieen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39382714en_US
bordeaux.journalSupportive Care in Canceren_US
bordeaux.page716en_US
bordeaux.volume32en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04730973
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Supportive%20Care%20in%20Cancer&rft.date=2024-10-09&rft.volume=32&rft.issue=11&rft.spage=716&rft.epage=716&rft.eissn=0941-4355&rft.issn=0941-4355&rft.au=TREILLET,%20Erwan&PERCEAU-CHAMBARD,%20Elise&ECONOMOS,%20Guillaume&CHEVALIER,%20Luc&PICARD,%20St%C3%A9phane&rft.genre=article


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