Tiny pills, big impacts: A systematic review on the endocrine disrupting effects of paediatric pharmaceuticals
| dc.rights.license | open | en_US |
| dc.contributor.author | TOURVIEILHE, L. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SALVO, Francesco
IDREF: 221043470 | |
| dc.contributor.author | BRÉANT, V. | |
| dc.contributor.author | KASSAI, B. | |
| dc.contributor.author | PORTEFAIX, A. | |
| dc.date.accessioned | 2024-10-16T08:10:58Z | |
| dc.date.available | 2024-10-16T08:10:58Z | |
| dc.date.issued | 2024-08-28 | |
| dc.identifier.issn | 1872-7077 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/202524 | |
| dc.description.abstractEn | Endocrine disrupting chemicals (EDCs) may impact children's health, with medicines as a possible exposure source. Objective: to assess the potential impact of substances in paediatric medications and essential oils on children as EDC. It is a systematic review of five databases including Medline following the PECOT approach. The review focused on publications about children exposed to medication (active ingredients or excipients of interest) and having developed clinical signs of endocrine dysfunction. Out of 946 studies identified, 28 studies were included. They revealed that parabens, lavender essential oils and anti-epileptics are the most identified pharmaceutical products. The reported outcomes relate to puberty, thyroid disorders, obesity and growth. The evidence indicates potential risks, but the overall quality of available data is limited. This systematic review exposes a lack of robust evidence linking paediatric medication exposure to EDC, predominantly relying on case reports. It cautions about potential conflicts of interest. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Endocrine disorders | |
| dc.subject.en | Environmental health | |
| dc.subject.en | Essential oils | |
| dc.subject.en | Medication | |
| dc.subject.en | Parabens | |
| dc.subject.en | Pediatrics | |
| dc.title.en | Tiny pills, big impacts: A systematic review on the endocrine disrupting effects of paediatric pharmaceuticals | |
| dc.title.alternative | Environ Toxicol Pharmacol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.etap.2024.104549 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 39208995 | en_US |
| bordeaux.journal | Environmental Toxicology and Pharmacology | en_US |
| bordeaux.page | 104549 | en_US |
| bordeaux.volume | 111 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | AHEAD_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04739191 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-10-16T08:10:59Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Toxicology%20and%20Pharmacology&rft.date=2024-08-28&rft.volume=111&rft.spage=104549&rft.epage=104549&rft.eissn=1872-7077&rft.issn=1872-7077&rft.au=TOURVIEILHE,%20L.&SALVO,%20Francesco&BR%C3%89ANT,%20V.&KASSAI,%20B.&PORTEFAIX,%20A.&rft.genre=article |
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