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A peripheral cytotoxic nk-like cd eight t-cell subset predicts at onset an aggressive course of multiple sclerosis

dc.rights.licenseopenen_US
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
hal.structure.identifierCentre d'investigation clinique (CIC) de Nantes -CIC Plurithématique [CIC 0004 - Nantes]
dc.contributor.authorLAPLAUD, David‐axel
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorSHAH, Sita
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorDUGAST, Emilie
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorGARCIA, Alexandra
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorFOURGEUX, Cynthia
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorGOURAIN, Victor
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorBOUSSAMET, Léo
hal.structure.identifierCIC Plurithématique de Nantes
dc.contributor.authorLEFRÈRE, Fabienne
hal.structure.identifierCIC Plurithématique de Nantes
dc.contributor.authorMOYON, Melinda
hal.structure.identifierCIC Plurithématique de Nantes
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorLEJEUNE, Flora
hal.structure.identifierCIC Plurithématique de Nantes
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorWIERTLEWSKI, Sandrine
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
hal.structure.identifierService de Neurologie [CHU Nimes] [Pôle NIRR]
dc.contributor.authorTHOUVENOT, Eric
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorAGHERBI, Hanane
hal.structure.identifierCentre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL]
hal.structure.identifierObservatoire Français de la Sclérose En Plaques [Lyon] [OFSEP]
dc.contributor.authorCASEY, Romain
hal.structure.identifierCentre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL]
hal.structure.identifierObservatoire Français de la Sclérose En Plaques [Lyon] [OFSEP]
hal.structure.identifierUniversité Claude Bernard Lyon 1 [UCBL]
dc.contributor.authorVUKUSIC, Sandra
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurélie
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
hal.structure.identifierCentre d'Investigation Clinique [Rennes] [CIC]
dc.contributor.authorLE PAGE, Emmanuelle
hal.structure.identifierDépartement de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier]
dc.contributor.authorLABAUGE, Pierre
hal.structure.identifierService de neurologie [CHRU Nancy]
dc.contributor.authorMATHEY, Guillaume
hal.structure.identifierLille Neurosciences & Cognition - U 1172 [LilNCog]
hal.structure.identifierCentre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] [CRC-SEP Nord-Pas de Calais]
dc.contributor.authorZÉPHYR, Thi Hélène
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorNICOT, Arnaud
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorPOSCHMANN, Jeremie
hal.structure.identifierCentre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology [U1064 Inserm - CR2TI]
dc.contributor.authorBERTHELOT, Laureline
dc.date.accessioned2024-10-15T14:40:37Z
dc.date.available2024-10-15T14:40:37Z
dc.date.issued2023-10
dc.date.conference2023-10-11
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202509
dc.description.abstractEnIntroduction: Multiple sclerosis (MS) is an autoimmune disease due to chronic inflammation in the central nervous system (CNS) whose prognosis is still uncertain at disease onset.Objectives/Aims: In an effort to anticipate disease severity, we founded the OutcoMS project, in which we aim to unravel mechanisms behind a poor outcome in MS, through the use of transcriptomics at disease onset. For that, we classified patients in aggressive or non-aggressive disease according to the use of high efficacy treatments during the two first years of the disease.Methods: In a first cohort, we collected peripheral blood mononuclear cells (PBMCs) from 22 patients at their first clinical episode during clinically isolated syndrome (CIS). After >2 years, patients were sorted into 11 non-aggressive MS and 11 aggressive MS. Samples were matched with PBMCs from 11 healthy volunteers (HV) and sequenced using scRNAseq technology. Transcriptomic results were then confirmed at the protein level in a second larger cohort of 60 CIS patients composed of 29 evolving toward a non-aggressive and 31 toward an aggressive MS, and 30 HV from the OFSEP cohort with a flow cytometry assay performed on PBMCs.Results: While subsets of CD4+ T cells discriminate MS patients and HV well, we identified a subset of CD8+ T cells that is increased in CIS patients that later convert to aggressive MS compared to non-aggressive MS. This CD8+ T cell population displays a memory phenotype and cytotoxic activity similar to natural killer cells. The increase in this subset in aggressive MS was confirmed using flow cytometry on the OFSEP cohort. Furthermore, a high frequency of these cells showed predictive value for aggressive MS at onset (AUC of 0.673). When combined with sNfL(serum neurofilament light chain) and sGFAP (serum glial fibrillary acidic protein), the AUC increased to 0.843.Conclusion: Our data suggests that severe forms of MS may be driven by a subset of cytotoxic memory CD8+ T cells with NK-like properties. The frequency of this subset of cells in the blood of MS patients, in association with sNfL and sGFAP, can be used as a predictive tool at the first demyelinating event to identify patients who will require high efficacy treatment.
dc.language.isoENen_US
dc.publisherSage Publications Ltden_US
dc.title.enA peripheral cytotoxic nk-like cd eight t-cell subset predicts at onset an aggressive course of multiple sclerosis
dc.typeCommunication dans un congrèsen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.pageP533en_US
bordeaux.volume29en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue3Sen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.conference.title9th Joint ECTRIMS-ACTRIMS meetingen_US
bordeaux.conference.cityMilanen_US
bordeaux.import.sourcehal
hal.identifierhal-04732340
hal.version1
hal.invitednonen_US
hal.proceedingsouien_US
hal.conference.organizerEuropean Commmittee for Treatment and Research in Multiple Sclerosis (ECTRIMS)en_US
hal.conference.organizerAmericas Commmittee for Treatment and Research in Multiple Sclerosis (ACTRIMS)en_US
hal.conference.end2023-10-13
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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