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CD8+ T-cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCABRAL-PICCIN, Mariela
dc.contributor.authorBRICENO, Olivia
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorPAPAGNO, Laura
dc.contributor.authorLIOUVILLE, Benjamin
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorWHITE, Eoghann
dc.contributor.authorPERDOMO-CELIS, Federico
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorAUTAA, Gaelle
dc.contributor.authorVOLANT, Stevenn
dc.contributor.authorLLEWELLYN-LACEY, Sian
dc.contributor.authorFROMENTIN, Rémi
dc.contributor.authorCHOMONT, Nicolas
dc.contributor.authorPRICE, David
dc.contributor.authorSAEZ-CIRION, Asier
dc.contributor.authorLAMBOTTE, Olivier
dc.contributor.authorKATLAMA, Christine
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorAPPAY, Victor
dc.date.accessioned2024-10-14T12:44:58Z
dc.date.available2024-10-14T12:44:58Z
dc.date.issued2024-02-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202479
dc.description.abstractEnBackground:The induction of de novo CD8+T-cell responses is essential for protective antiviral immunity, but this process is often impaired in people with HIV-1 (PWH). We investigated the extent to which the immune competence of naive CD8+T cells, a key determinant of priming efficacy, could be preserved or restored in PWH via long-term antiretroviral therapy (ART).Methods:We used flow cytometry, molecular analyses of gene transcription and telomere length, and a fully validated priming assay to characterize naive CD8+T cells ex vivo and evaluate the induction of antigen-specific effector/memory CD8+T cells in vitro, comparing age-matched healthy uninfected donors (HUDs), PWH on ART, and natural HIV-1 controllers (HICs).Results:We found that naive CD8+T cells were numerically reduced and exhibited a trend toward shorter telomere lengths in PWH on ART compared with HUDs and HICs. These features associated with impaired priming efficacy. However, we also found that naive CD8+T cells were fully equipped proliferatively and transcriptionally in PWH on ART, enabling the generation of antigen-specific effector/memory CD8+T cells with functional and phenotypic attributes comparable to those primed from HUDs.Conclusion:Our data suggest that naive CD8+T cells in PWH on ART are intrinsically capable of generating functionally and phenotypically intact effector/memory CD8+T cells in response to antigen, despite evidence of senescence and an overall numerical reduction that compromises priming efficacy relative to HUDs and HICs.
dc.language.isoENen_US
dc.title.enCD8+ T-cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/QAD.0000000000003746en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed37800637en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.page161-166en_US
bordeaux.volume38en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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