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Presentation and outcomes of Lassa fever in children in Nigeria: a prospective cohort study (LASCOPE)

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorDUVIGNAUD, Alexandre
dc.contributor.authorETAFO, Ijeoma C
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorJASPARD, Marie
dc.contributor.authorSALAU, Qasim
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorSERRA, Beatrice
dc.contributor.authorKAREEM, Abiodun J
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorJUCHET, Sylvain
dc.contributor.authorJEGEDE, Tolulope O
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorGABILLARD, Delphine
dc.contributor.authorABIDOYE, Abiodun T
dc.contributor.authorLE GAL, Camille
dc.contributor.authorABEJEGAH, Chukwuyem
dc.contributor.authorOWHIN, Sampson
dc.contributor.authorOKWARAEKE, Kevin
dc.contributor.authorDOUTCHI, Mahamadou
dc.contributor.authorVIHUNDIRA, Jackson Katembo
dc.contributor.authorBESONG-LACHE, Rene-M
dc.contributor.authorSERI, Benjamin
dc.contributor.authorBERERD-CAMARA, Marion
dc.contributor.authorSALAM, Alex P A
dc.contributor.authorOLAYINKA, Adebola
dc.contributor.authorHORBY, Peter
dc.contributor.authorOGBAINI-EMOVON, Ephraim
dc.contributor.authorDURAFFOUR, Sophie
dc.contributor.authorAHMED, Liasu A
dc.contributor.authorGUNTHER, Stephan
dc.contributor.authorADEDOSU, Akinola N
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorANGLARET, Xavier
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorMALVY, Denis
dc.contributor.authorLANG, Hans J
dc.contributor.authorAYODEJI, Oladele O
dc.date.accessioned2024-10-10T13:47:20Z
dc.date.available2024-10-10T13:47:20Z
dc.date.issued2024-08-21
dc.identifier.issn2048-7207en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202388
dc.description.abstractEnBACKGROUND: Data on the presentation, management and outcomes of Lassa fever (LF) in children are limited. METHODS: Description of the clinical and biological features, treatment and outcomes of RT-PCR-confirmed LF in children aged under 15, enrolled in the LASCOPE prospective cohort study in Nigeria between April 2018 and February 2023. RESULTS: 124 children (aged under 12 months: 19; over 12 months: 105) were hospitalized with RT-PCR-confirmed LF. All received intravenous ribavirin. During follow-up, 99/124 (80%) had fever; 71/124 (57%) had digestive symptoms, vomiting (n = 56/122, 46%) and abdominal pain (n = 34/78 aged ≥ 5 years, 44%) more often than diarrhea (n = 19/124, 15%); 17/124 (14%) had hemorrhagic signs; 44/112 (39%) had a hematocrit lower than 25%, of whom 32/44 (73%) received transfusions; 44/88 (50%) developed hypotension; 18/112 (16.1%) developed KDIGO ≥ 2 acute kidney injury; 10/112 (8.9%) had KDIGO 3 acute kidney failure; 4/124 (3.2%) underwent renal replacement therapy. 7 children died, including 4 aged under 12 months (case fatality rate: under 12 months - 22%, 95% CI 7 - 48%; over 12 months - 2.9%, 95% CI 0.7 - 8.7%). In univariable analysis, age (p=0.003), impaired consciousness (p=0.026), and Lassa RT-PCR Ct value (p=0.006) were associated to Day 30 mortality. CONCLUSIONS: The fatality rate for children over 12 months hospitalized with LF was lower than that previously reported for adults. Hypotension and acute kidney injury were the most frequent organ dysfunctions. Bleeding was relatively infrequent. Anemia and the need for transfusion were common, the relative contribution of ribavirin-induced hemolysis being unknown.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enLassa Fever
dc.subject.enNigeria
dc.subject.enAcute Kidney Injury
dc.subject.enAnemia
dc.subject.enChildren
dc.subject.enPrognosis
dc.title.enPresentation and outcomes of Lassa fever in children in Nigeria: a prospective cohort study (LASCOPE)
dc.title.alternativeJ Pediatric Infect Dis Socen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/jpids/piae083en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39167706en_US
bordeaux.journalJournal of the Pediatric Infectious Diseases Societyen_US
bordeaux.pagepiae083en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.identifierhal-04730829
hal.version1
hal.date.transferred2024-10-10T13:47:24Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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