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Discrimination of the Veterans Aging Cohort Study Index 2.0 for Predicting Cause-specific Mortality Among Persons With HIV in Europe and North America

dc.rights.licenseopenen_US
dc.contributor.authorAMBIA, Julie
dc.contributor.authorINGLE, Suzanne M
dc.contributor.authorMCGINNIS, Kathleen
dc.contributor.authorPANTAZIS, Nikos
dc.contributor.authorSILVERBERG, Michael J
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorKUSEJKO, Katharina
dc.contributor.authorCRANE, Heidi
dc.contributor.authorVAN SIGHEM, Ard
dc.contributor.authorSARCLETTI, Mario
dc.contributor.authorCOZZI-LEPRI, Alessandro
dc.contributor.authorDOMINGO, Pere
dc.contributor.authorJARRIN, Inma
dc.contributor.authorWYEN, Christoph
dc.contributor.authorHESSAMFAR, Mojgan
dc.contributor.authorZHANG, Lei
dc.contributor.authorCAVASSINI, Matthias
dc.contributor.authorBERENGUER, Juan
dc.contributor.authorSTERLING, Timothy R
dc.contributor.authorREISS, Peter
dc.contributor.authorABGRALL, Sophie
dc.contributor.authorGILL, M John
dc.contributor.authorJUSTICE, Amy
dc.contributor.authorSTERNE, Jonathan A C
dc.contributor.authorTRICKEY, Adam
dc.date.accessioned2024-10-09T12:26:42Z
dc.date.available2024-10-09T12:26:42Z
dc.date.issued2024-07-01
dc.identifier.issn2328-8957en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202345
dc.description.abstractEnBACKGROUND: Predicting cause-specific mortality among people with HIV (PWH) could facilitate targeted care to improve survival. We assessed discrimination of the Veterans Aging Cohort Study (VACS) Index 2.0 in predicting cause-specific mortality among PWH on antiretroviral therapy (ART). METHODS: Using Antiretroviral Therapy Cohort Collaboration data for PWH who initiated ART between 2000 and 2018, VACS Index 2.0 scores (higher scores indicate worse prognosis) were calculated around a randomly selected visit date at least 1 year after ART initiation. Missingness in VACS Index 2.0 variables was addressed through multiple imputation. Cox models estimated associations between VACS Index 2.0 and causes of death, with discrimination evaluated using Harrell's C-statistic. Absolute mortality risk was modelled using flexible parametric survival models. RESULTS: Of 59 741 PWH (mean age: 43 years; 80% male), the mean VACS Index 2.0 at baseline was 41 (range: 0-129). For 2425 deaths over 168 162 person-years follow-up (median: 2.6 years/person), AIDS (n = 455) and non-AIDS-defining cancers (n = 452) were the most common causes. Predicted 5-year mortality for PWH with a mean VACS Index 2.0 score of 38 at baseline was 1% and approximately doubled for every 10-unit increase. The 5-year all-cause mortality C-statistic was .83. Discrimination with the VACS Index 2.0 was highest for deaths resulting from AIDS (0.91), liver-related (0.91), respiratory-related (0.89), non-AIDS infections (0.87), and non-AIDS-defining cancers (0.83), and lowest for suicides/accidental deaths (0.65). CONCLUSIONS: For deaths among PWH, discrimination with the VACS Index 2.0 was highest for deaths with measurable physiological causes and was lowest for suicide/accidental deaths.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enC-Statistic
dc.subject.enVACS
dc.subject.enAbsolute Risk
dc.subject.enMultiple Imputation
dc.subject.enPrognosis
dc.title.enDiscrimination of the Veterans Aging Cohort Study Index 2.0 for Predicting Cause-specific Mortality Among Persons With HIV in Europe and North America
dc.title.alternativeOpen Forum Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ofid/ofae333en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39015347en_US
bordeaux.journalOpen Forum Infectious Diseasesen_US
bordeaux.pageofae333en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.identifierhal-04728165
hal.version1
hal.date.transferred2024-10-09T12:26:47Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Open%20Forum%20Infectious%20Diseases&rft.date=2024-07-01&rft.volume=11&rft.issue=7&rft.spage=ofae333&rft.epage=ofae333&rft.eissn=2328-8957&rft.issn=2328-8957&rft.au=AMBIA,%20Julie&INGLE,%20Suzanne%20M&MCGINNIS,%20Kathleen&PANTAZIS,%20Nikos&SILVERBERG,%20Michael%20J&rft.genre=article


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